{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T04:52:35Z","timestamp":1788324755578,"version":"build-2803163510"},"reference-count":62,"publisher":"Wiley","issue":"25","license":[{"start":{"date-parts":[[2023,6,28]],"date-time":"2023-06-28T00:00:00Z","timestamp":1687910400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFA1105502"],"award-info":[{"award-number":["2022YFA1105502"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Retinal degeneration, characterized by the progressive loss of retinal neurons, is the leading cause of incurable visual impairment. Retinal progenitor cells (RPCs)\u2010based transplantation can facilitate sight restoration, but the clinical efficacy of this process is compromised by the imprecise neurogenic differentiation of RPCs and undermining function of transplanted cells surrounded by severely oxidative retinal lesions. Here, it is shown that ultrathin niobium carbide (Nb<jats:sub>2<\/jats:sub>C) MXene enables performance enhancement of RPCs for retinal regeneration. Nb<jats:sub>2<\/jats:sub>C MXene with moderate photothermal effect markedly improves retinal neuronal differentiation of RPCs by activating intracellular signaling, in addition to the highly effective RPC protection by scavenging free radicals concurrently, which has been solidly evidenced by the comprehensive biomedical assessments and theoretical calculations. A dramatically increased neuronal differentiation is observed upon subretinal transplantation of MXene\u2010assisted RPCs into the typical retinal degeneration 10 (rd10) mice, thereby contributing to the efficient restoration of retinal architecture and visual function. The dual\u2010intrinsic function of MXene synergistically aids RPC transplantation, which represents an intriguing paradigm in vision\u2010restoration research filed, and will broaden the multifunctionality horizon of nanomedicine.<\/jats:p>","DOI":"10.1002\/advs.202302747","type":"journal-article","created":{"date-parts":[[2023,6,28]],"date-time":"2023-06-28T12:45:11Z","timestamp":1687956311000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Bifunctional MXene\u2010Augmented Retinal Progenitor Cell Transplantation for Retinal Degeneration"],"prefix":"10.1002","volume":"10","author":[{"given":"Zhimin","family":"Tang","sequence":"first","affiliation":[{"name":"Department of Ophthalmology Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine  Shanghai 200011 P. R. China"},{"name":"Shanghai Key Laboratory of Orbital Diseases and Ocular Oncology  Shanghai 200011 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine  Shanghai 200011 P. R. China"},{"name":"Shanghai Key Laboratory of Orbital Diseases and Ocular Oncology  Shanghai 200011 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huijing","family":"Xiang","sequence":"additional","affiliation":[{"name":"Materdicine Lab School of Life Sciences Shanghai University  Shanghai 200444 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyue","family":"Dai","sequence":"additional","affiliation":[{"name":"Materdicine Lab School of Life Sciences Shanghai University  Shanghai 200444 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaolin","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine  Shanghai 200011 P. R. China"},{"name":"Shanghai Key Laboratory of Orbital Diseases and Ocular Oncology  Shanghai 200011 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yahan","family":"Ju","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine  Shanghai 200011 P. R. China"},{"name":"Shanghai Key Laboratory of Orbital Diseases and Ocular Oncology  Shanghai 200011 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ni","family":"Ni","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine  Shanghai 200011 P. R. China"},{"name":"Shanghai Key Laboratory of Orbital Diseases and Ocular Oncology  Shanghai 200011 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine  Shanghai 200011 P. R. China"},{"name":"Shanghai Key Laboratory of Orbital Diseases and Ocular Oncology  Shanghai 200011 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiqin","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine  Shanghai 200011 P. R. China"},{"name":"Shanghai Key Laboratory of Orbital Diseases and Ocular Oncology  Shanghai 200011 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine  Shanghai 200011 P. R. China"},{"name":"Shanghai Key Laboratory of Orbital Diseases and Ocular Oncology  Shanghai 200011 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianqun","family":"Fan","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine  Shanghai 200011 P. R. China"},{"name":"Shanghai Key Laboratory of Orbital Diseases and Ocular Oncology  Shanghai 200011 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun","family":"Su","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine  Shanghai 200011 P. R. China"},{"name":"Shanghai Key Laboratory of Orbital Diseases and Ocular Oncology  Shanghai 200011 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8206-3325","authenticated-orcid":false,"given":"Yu","family":"Chen","sequence":"additional","affiliation":[{"name":"Materdicine Lab School of Life Sciences Shanghai University  Shanghai 200444 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Gu","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine  Shanghai 200011 P. R. China"},{"name":"Shanghai Key Laboratory of Orbital Diseases and Ocular Oncology  Shanghai 200011 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,6,28]]},"reference":[{"key":"e_1_2_8_1_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.preteyeres.2021.100975"},{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41418-020-00636-4"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.preteyeres.2021.100941"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2022.01.002"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-017-1183-y"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41551-021-00836-4"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2021.101971"},{"key":"e_1_2_8_7_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0604056103"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkab003"},{"key":"e_1_2_8_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201705684"},{"key":"e_1_2_8_8_3","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2021.121279"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-021-04336-y"},{"key":"e_1_2_8_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202105586"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1039\/D0NR02319A"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.39471"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.nanolett.1c04534"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1914345117"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/nano11051216"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.0c08045"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.8b09327"},{"key":"e_1_2_8_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2021.06.016"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23031761"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stemcr.2018.01.032"},{"key":"e_1_2_8_18_2","doi-asserted-by":"publisher","DOI":"10.3390\/cells12071094"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.7b07818"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201506154"},{"key":"e_1_2_8_20_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja2010175"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.nanolett.9b05035"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2018.12.015"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202104747"},{"key":"e_1_2_8_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2018.12.008"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1716164115"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202005578"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells10010064"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/smtd.202100848"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.0c16645"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2008.01.038"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.9b22258"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202100895"},{"key":"e_1_2_8_31_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41418-020-00653-3"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jpclett.9b01735"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/acel.13444"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.14-14696"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-71626-2"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stemcr.2020.12.007"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncb1720"},{"key":"e_1_2_8_37_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI85193"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature02069"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms13029"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/stem.2552"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.00824"},{"key":"e_1_2_8_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2008.10.015"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature05161"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI154619"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox12010098"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1103\/PhysRevB.54.11169"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1103\/PhysRevLett.77.3865"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1063\/1.3382344"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1038\/35097186"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.15303"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-35503-y"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1167\/tvst.9.11.18"}],"container-title":["Advanced Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/advs.202302747","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T17:11:53Z","timestamp":1759770713000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/advs.202302747"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6,28]]},"references-count":62,"journal-issue":{"issue":"25","published-print":{"date-parts":[[2023,9]]}},"alternative-id":["10.1002\/advs.202302747"],"URL":"https:\/\/doi.org\/10.1002\/advs.202302747","archive":["Portico"],"relation":{},"ISSN":["2198-3844","2198-3844"],"issn-type":[{"value":"2198-3844","type":"print"},{"value":"2198-3844","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,6,28]]},"assertion":[{"value":"2023-04-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-06-28","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"2302747"}}