{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T12:03:37Z","timestamp":1787313817403,"version":"build-2736575974"},"reference-count":71,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,11,20]],"date-time":"2023-11-20T00:00:00Z","timestamp":1700438400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2022R1C1C2010406"],"award-info":[{"award-number":["2022R1C1C2010406"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2019R1A2C1084371"],"award-info":[{"award-number":["2019R1A2C1084371"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2019R1A2C2086618"],"award-info":[{"award-number":["2019R1A2C2086618"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2018R1A5A1024340"],"award-info":[{"award-number":["2018R1A5A1024340"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2019M3A9A8065669"],"award-info":[{"award-number":["2019M3A9A8065669"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2022M3E5F2017408"],"award-info":[{"award-number":["2022M3E5F2017408"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004080","name":"Korea Drug Development Fund","doi-asserted-by":"publisher","award":["RS\u20102021\u2010DD120784(HN21C0923000021)"],"award-info":[{"award-number":["RS\u20102021\u2010DD120784(HN21C0923000021)"]}],"id":[{"id":"10.13039\/501100004080","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004080","name":"Korea Drug Development Fund","doi-asserted-by":"publisher","award":["RS\u20102021\u2010DD120712(HN21C0882)"],"award-info":[{"award-number":["RS\u20102021\u2010DD120712(HN21C0882)"]}],"id":[{"id":"10.13039\/501100004080","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003625","name":"Ministry of Health and Welfare","doi-asserted-by":"publisher","award":["HR22C1832"],"award-info":[{"award-number":["HR22C1832"]}],"id":[{"id":"10.13039\/501100003625","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010418","name":"Institute for Information and communications Technology Promotion","doi-asserted-by":"publisher","award":["IITP\u20102023\u20102020\u20100\u201001808"],"award-info":[{"award-number":["IITP\u20102023\u20102020\u20100\u201001808"]}],"id":[{"id":"10.13039\/501100010418","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Activation of hypoxia\u2010inducible factor 1\u03b1 (HIF1\u03b1) contributes to blood\u2010retinal barrier (BRB) breakdown and pathological neovascularization responsible for vision loss in ischemic retinal diseases. During disease progression, mitochondrial biology is altered to adapt to the ischemic environment created by initial vascular dysfunction, but the mitochondrial adaptive mechanisms, which ultimately contribute to the pathogenesis of ischemic retinopathy, remain incompletely understood. In the present study, it is identified that expression of mitochondrial chaperone tumor necrosis factor receptor\u2010associated protein 1 (TRAP1) is essential for BRB breakdown and pathologic retinal neovascularization in mouse models mimicking ischemic retinopathies. Genetic\n                    <jats:italic>Trap1<\/jats:italic>\n                    ablation or treatment with small molecule TRAP1 inhibitors, such as mitoquinone (MitoQ) and SB\u2010U015, alleviate retinal pathologies via proteolytic HIF1\u03b1 degradation, which is mediated by opening of the mitochondrial permeability transition pore and activation of calcium\u2010dependent protease calpain\u20101. These findings suggest that TRAP1 can be a promising target for the development of new treatments against ischemic retinopathy, such as retinopathy of prematurity and proliferative diabetic retinopathy.\n                  <\/jats:p>","DOI":"10.1002\/advs.202302776","type":"journal-article","created":{"date-parts":[[2023,11,21]],"date-time":"2023-11-21T16:30:12Z","timestamp":1700584212000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Targeting the Mitochondrial Chaperone TRAP1 Alleviates Vascular Pathologies in Ischemic Retinopathy"],"prefix":"10.1002","volume":"11","author":[{"given":"So\u2010Yeon","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Biological Sciences Ulsan National Institutes of Science and Technology (UNIST)  Ulsan 44919 Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nam Gu","family":"Yoon","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences Ulsan National Institutes of Science and Technology (UNIST)  Ulsan 44919 Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin Young","family":"Im","sequence":"additional","affiliation":[{"name":"SmartinBio Inc.  Cheongju 28160 Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji Hye","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences Ulsan National Institutes of Science and Technology (UNIST)  Ulsan 44919 Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juhee","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, School of Medicine Kyungpook National University, Kyungpook National University Hospital  Daegu 41944 Republic of Korea"},{"name":"Cell &amp; Matrix Research Institute Kyungpook National University  Daegu 41944 Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yujin","family":"Jeon","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, School of Medicine Kyungpook National University, Kyungpook National University Hospital  Daegu 41944 Republic of Korea"},{"name":"Cell &amp; Matrix Research Institute Kyungpook National University  Daegu 41944 Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young Jae","family":"Choi","sequence":"additional","affiliation":[{"name":"Bioanalysis and Pharmacokinetics Research Group Korea Institute of Toxicology  Daejeon 34114 Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jong\u2010Hwa","family":"Lee","sequence":"additional","affiliation":[{"name":"Bioanalysis and Pharmacokinetics Research Group Korea Institute of Toxicology  Daejeon 34114 Republic of Korea"},{"name":"Department of Human and Environment Toxicology University of Science &amp; Technology  Daejeon 34113 Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akiyoshi","family":"Uemura","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Visual Science Nagoya City University Graduate School of Medical Sciences  Nagoya 467\u20108601 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6911-3765","authenticated-orcid":false,"given":"Dong Ho","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, School of Medicine Kyungpook National University, Kyungpook National University Hospital  Daegu 41944 Republic of Korea"},{"name":"Cell &amp; Matrix Research Institute Kyungpook National University  Daegu 41944 Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5902-0549","authenticated-orcid":false,"given":"Byoung Heon","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences Ulsan National Institutes of Science and Technology (UNIST)  Ulsan 44919 Republic of Korea"},{"name":"SmartinBio Inc.  Cheongju 28160 Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,11,20]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2012.02.035"},{"key":"e_1_2_9_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2016.07.002"},{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm.2017.66"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcb.2014.03.005"},{"key":"e_1_2_9_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2007.08.028"},{"key":"e_1_2_9_3_3","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.275.5.3305"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-18-2558"},{"key":"e_1_2_9_4_2","doi-asserted-by":"publisher","DOI":"10.1186\/1476-4598-13-148"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.preteyeres.2020.100881"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.2337\/dbi18-0016"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1005073"},{"key":"e_1_2_9_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)62124-3"},{"key":"e_1_2_9_7_3","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)60178-6"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41580-020-0227-y"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.93751"},{"key":"e_1_2_9_9_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI42142"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41574-020-00451-4"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2016.06.055"},{"key":"e_1_2_9_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2011.07.005"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41433-018-0138-8"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2009.187"},{"key":"e_1_2_9_13_2","first-page":"101","volume":"35","author":"Smith L. E.","year":"1994","journal-title":"Invest Ophthalmol"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.2337\/db09-1420"},{"key":"e_1_2_9_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3723"},{"key":"e_1_2_9_14_3","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2121875119"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI126655"},{"key":"e_1_2_9_15_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI120879"},{"key":"e_1_2_9_15_3","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-011-2081-0"},{"key":"e_1_2_9_15_4","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2009.12.002"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.92.3.905"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-021-03716-6"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2021.108718"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.04-1361"},{"key":"e_1_2_9_19_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1522014113"},{"key":"e_1_2_9_19_3","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2052"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.47.3.445"},{"key":"e_1_2_9_20_2","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.18-25372"},{"key":"e_1_2_9_21_1","first-page":"1999","volume":"284","author":"Holash J.","year":"1994","journal-title":"Science"},{"key":"e_1_2_9_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2022.03.004"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19040942"},{"key":"e_1_2_9_22_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.601639"},{"key":"e_1_2_9_22_3","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.14-14864"},{"key":"e_1_2_9_22_4","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.117.310337"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2013.04.019"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja511893n"},{"key":"e_1_2_9_24_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.2c01633"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibs.2008.08.002"},{"key":"e_1_2_9_25_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M204733200"},{"key":"e_1_2_9_25_3","first-page":"2478","volume":"62","author":"Mabjeesh N. J.","year":"2002","journal-title":"Cancer Res."},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-5521(01)00056-4"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.e05-08-0770"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/s12276-019-0360-x"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vph.2012.02.009"},{"key":"e_1_2_9_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(02)00659-1"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/nsb0402-239"},{"key":"e_1_2_9_30_2","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00029.2002"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2004.08.025"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.1c07099"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.preteyeres.2015.06.002"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41580-021-00433-y"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41422-020-0388-4"},{"key":"e_1_2_9_35_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M408100200"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1007374"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2016-0057"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1414264"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-008-1078-9"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.15252\/emmm.201810204"},{"key":"e_1_2_9_40_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1423765112"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI37613"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd3801"},{"key":"e_1_2_9_43_1","volume":"7","author":"Liu X.","year":"2017","journal-title":"Bio Protoc"}],"container-title":["Advanced Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/advs.202302776","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T14:38:42Z","timestamp":1759761522000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/advs.202302776"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11,20]]},"references-count":71,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2024,1]]}},"alternative-id":["10.1002\/advs.202302776"],"URL":"https:\/\/doi.org\/10.1002\/advs.202302776","archive":["Portico"],"relation":{},"ISSN":["2198-3844","2198-3844"],"issn-type":[{"value":"2198-3844","type":"print"},{"value":"2198-3844","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,11,20]]},"assertion":[{"value":"2023-05-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-11-20","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"2302776"}}