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A mosaic ferritin nanoparticle vaccine is developed that co\u2010displays the spike receptor\u2010binding domains of SARS\u2010CoV, MERS\u2010CoV, and SARS\u2010CoV\u20102 Wild\u2010type (WT) strain and evaluated its immunogenicity and protective efficacy in mice and nonhuman primates. A low dose of 10\u00a0\u00b5g administered at a 21\u2010day interval induced a Th1\u2010biased immune response in mice and elicited robust cross\u2010reactive neutralizing antibody responses against a variety of \u03b2\u2010CoVs, including a series of SARS\u2010CoV\u20102 variants. It is also able to effectively protect against challenges of SARS\u2010CoV, MERS\u2010CoV, and SARS\u2010CoV\u20102 variants in not only young mice but also the more vulnerable mice through induction of long\u2010lived immunity. Together, these results suggest that this mosaic 3\u2010RBD nanoparticle has the potential to be developed as a pan\u2010\u03b2\u2010CoV vaccine.<\/jats:p>","DOI":"10.1002\/advs.202303366","type":"journal-article","created":{"date-parts":[[2023,12,17]],"date-time":"2023-12-17T21:35:49Z","timestamp":1702848949000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Mosaic RBD Nanoparticles Elicit Protective Immunity Against Multiple Human Coronaviruses in Animal Models"],"prefix":"10.1002","volume":"11","author":[{"given":"Yanjun","family":"Zhang","sequence":"first","affiliation":[{"name":"State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease Guangzhou Institute of Respiratory Health the First Affiliated Hospital of Guangzhou Medical University  Guangzhou 510300 P. R. 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