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Recently developed cardiac patches provide mechanical support and additional conductive paths to promote electrical signal propagation in the MI area to synchronize cardiac excitation and contraction. Cardiac patches based on conductive polymers offer attractive features; however, the modest levels of elasticity and high impedance interfaces limit their mechanical and electrical performance. These structures also operate as permanent implants, even in cases where their utility is limited to the healing period of tissue damaged by the MI. The work presented here introduces a highly conductive cardiac patch that combines bioresorbable metals and polymers together in a hybrid material structure configured in a thin serpentine geometry that yields elastic mechanical properties. Finite element analysis guides optimized choices of layouts in these systems. Regular and synchronous contraction of human induced pluripotent stem cell\u2010derived cardiomyocytes on the cardiac patch and ex vivo studies offer insights into the essential properties and the bio\u2010interface. These results provide additional options in the design of cardiac patches to treat MI and other cardiac disorders.<\/jats:p>","DOI":"10.1002\/advs.202303429","type":"journal-article","created":{"date-parts":[[2023,7,30]],"date-time":"2023-07-30T22:26:01Z","timestamp":1690755961000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["Materials and Design Approaches for a Fully Bioresorbable, Electrically Conductive and Mechanically Compliant Cardiac Patch Technology"],"prefix":"10.1002","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3268-9661","authenticated-orcid":false,"given":"Hanjun","family":"Ryu","sequence":"first","affiliation":[{"name":"Department of Advanced Materials Engineering Chung\u2010Ang University  Anseong 17546 Republic of Korea"},{"name":"Department of Intelligence Energy and Industry Chung\u2010Ang University  Seoul 06974 Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinlong","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering Northwestern University  Evanston IL 60208 USA"},{"name":"Center for Advanced Regenerative Engineering Northwestern University  Evanston IL 60208 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaoqian","family":"Xie","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Structural Analysis Optimization and CAE Software for Industrial Equipment Dalian University of Technology  Dalian 116024 P. 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