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In this study, the hypothesis is tested that impairments in neurovascular coupling (NVC) responses and brain network function predict cognitive dysfunction in older adults. Cerebromicrovascular and working memory function of healthy young (<jats:italic>n<\/jats:italic> = 21, 33.2\u00b17.0 years) and aged (<jats:italic>n<\/jats:italic> = 30, 75.9\u00b16.9 years) participants are assessed.\u00a0To determine NVC responses and functional connectivity (FC) during a working memory (n\u2010back) paradigm, oxy\u2010 and deoxyhemoglobin concentration changes from the frontal cortex using functional near\u2010infrared spectroscopy are recorded. NVC responses are significantly impaired during the 2\u2010back task in aged participants, while the frontal networks are characterized by higher local and global connection strength, and dynamic FC (<jats:italic>p<\/jats:italic> &lt; 0.05). Both impaired NVC and increased FC correlate with age\u2010related decline in accuracy during the 2\u2010back task. These findings suggest that task\u2010related brain states in older adults require stronger functional connections to compensate for the attenuated NVC responses associated with working memory load.<\/jats:p>","DOI":"10.1002\/advs.202303516","type":"journal-article","created":{"date-parts":[[2023,12,29]],"date-time":"2023-12-29T01:10:32Z","timestamp":1703812232000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":46,"title":["Impaired Neurovascular Coupling and Increased Functional Connectivity in the Frontal Cortex Predict Age\u2010Related Cognitive Dysfunction"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4355-8103","authenticated-orcid":false,"given":"Peter","family":"Mukli","sequence":"first","affiliation":[{"name":"Oklahoma Center for Geroscience and Healthy Brain Aging University of Oklahoma Health Sciences Center  1122 NE 13th Street Oklahoma City OK 73117 USA"},{"name":"Vascular 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