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Single anti\u2010inflammation or anti\u2010infection treatment exhibits limited survival benefit for severe cases. Here a biodegradable tobramycin\u2010loaded magnesium micromotor (Mg\u2010Tob motor) is successfully developed as a potential hydrogen generator and active antibiotic deliverer for synergistic therapy of sepsis. The peritoneal fluid of septic mouse provides an applicable space for Mg\u2010water reaction. Hydrogen generated sustainably and controllably from the motor interface propels the motion to achieve active drug delivery along with attenuating hyperinflammation. The developed Mg\u2010Tob motor demonstrates efficient protection from anti\u2010inflammatory and antibacterial activity both in vitro and in vivo. Importantly, it prevents multiple organ failure and significantly improves the survival rate up to 87.5% in a high\u2010grade sepsis model with no survival, whereas only about half of mice survive with the individual therapies. This micromotor displays the superior therapeutic effect of synergistic hydrogen\u2010chemical therapy against sepsis, thus holding great promise to be an innovative and translational drug delivery system to treat sepsis or other inflammation\u2010related diseases in the near future.<\/jats:p>","DOI":"10.1002\/advs.202303759","type":"journal-article","created":{"date-parts":[[2023,10,12]],"date-time":"2023-10-12T01:12:31Z","timestamp":1697073151000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Micromotor\u2010Enabled Active Hydrogen and Tobramycin Delivery for Synergistic Sepsis Therapy"],"prefix":"10.1002","volume":"10","author":[{"given":"Yanzhen","family":"Song","sequence":"first","affiliation":[{"name":"NMPA Key Laboratory for Research and Evaluation of Drug Metabolism &amp; Guangdong Provincial Key Laboratory of New Drug Screening School of Pharmaceutical Sciences Southern Medical University  Guangzhou 510515 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruotian","family":"Zhang","sequence":"additional","affiliation":[{"name":"NMPA Key Laboratory for Research and Evaluation of Drug Metabolism &amp; 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