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However, the single shielding function and absence of physiological activity render conventional methods less useful in preventing adhesions in patients with MetS. To address this challenge, a convenient method is introduced for developing a novel tissue\u2010adhesive hydrogel called oxidized dextran\u2013metformin (ODE\u2013ME) via Schiff base linkages. This injectable ODE\u2013ME hydrogel exhibits excellent tissue\u2010adhesive properties and various physiological functions, particularly enhanced antibacterial effects. Furthermore, in vivo experiments demonstrate that the hydrogel can effectively alleviate hyperglycemia, reduce excessive inflammation, and improve fibrinolytic activity in MetS mice, thereby preventing adhesions and promoting incisional healing. The hydrogel concurrently isolates injured tissues and lowers the blood glucose levels immediately after surgery in mice. Therefore, the ODE\u2013ME hydrogel functions as a multifunctional barrier material and has potential for preventing postoperative peritoneal adhesions in patients with MetS in clinical settings.<\/jats:p>","DOI":"10.1002\/advs.202303767","type":"journal-article","created":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T21:12:07Z","timestamp":1697490727000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Multifunctional Oxidized Dextran\u2013Metformin as a Tissue\u2010Adhesive Hydrogel to Prevent Postoperative Peritoneal Adhesions in Patients with Metabolic Syndrome"],"prefix":"10.1002","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7349-8792","authenticated-orcid":false,"given":"Xi","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Gastrointestinal Surgery The Third Xiangya Hospital of Central South University  Tongzipo Road Changsha Hunan 410013 P. R. 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