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The abnormal narrowing leads to severe symptoms such as pain and nausea. Stents are an effective treatment. Compared with non\u2010degradable stents which require repeated removal, biodegradable stents have the advantage of reducing secondary injury related to endoscopic operation and patient burden. However, current biodegradable materials may cause tissue hyperplasia and the treatment method does not target etiology of stricture. So recurrence rates after biodegradable stent implantation are still high. Here, a biodegradable helical stent fabricated from biosynthetic P(3HB\u2010<jats:italic>co<\/jats:italic>\u20104HB) is reported. Tunable properties can be acquired through altering culture substrates. Stent shows shape memory in various solvents. The stent has an optimized design with helical structure and outer track. The self\u2010expanding of helical structure and double drainage realized by outer track greatly improve drainage of bile. Importantly, stent\u2010loading triamcinolone acetonide can inhibit proliferation of fibroblasts and reduce incidence of restricture. Therapeutic effect is also demonstrated in minipigs with biliary stricture. The results of minipig experiments show that biliary duct in treatment group is unobstructed and tissue hyperplasia is effectively inhibited.<\/jats:p>","DOI":"10.1002\/advs.202303779","type":"journal-article","created":{"date-parts":[[2023,8,8]],"date-time":"2023-08-08T09:15:17Z","timestamp":1691486117000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Biosynthetic Plastics as Tunable Elastic and Visible Stent with Shape\u2010Memory to Treat Biliary Stricture"],"prefix":"10.1002","volume":"10","author":[{"given":"Wei","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Gastroenterology Xinqiao Hospital Army Medical University  NO.183, Xinqiao Street Chongqing 400037 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaohui","family":"Luan","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Xinqiao Hospital Army Medical University  NO.183, Xinqiao Street Chongqing 400037 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenzhen","family":"Shu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Xinqiao Hospital Army Medical University  NO.183, Xinqiao Street Chongqing 400037 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaige","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Mechanical Engineering University of Manitoba  Winnipeg Manitoba MB R3T 2N2 Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tongchuan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Xinqiao Hospital Army Medical University  NO.183, Xinqiao Street Chongqing 400037 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuang","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Xinqiao Hospital Army Medical University  NO.183, Xinqiao Street Chongqing 400037 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaozhuo","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Mechanical Engineering University of Manitoba  Winnipeg Manitoba MB R3T 2N2 Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hangzong","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Xinqiao Hospital Army Medical University  NO.183, Xinqiao Street Chongqing 400037 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaosong","family":"Ye","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Xinqiao Hospital Army Medical University  NO.183, Xinqiao Street Chongqing 400037 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruijue","family":"Dan","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Xinqiao Hospital Army Medical University  NO.183, Xinqiao Street Chongqing 400037 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyan","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Xinqiao Hospital Army Medical University  NO.183, Xinqiao Street Chongqing 400037 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiming","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Xinqiao Hospital Army Medical University  NO.183, Xinqiao Street Chongqing 400037 China"},{"name":"Chongqing Municipality Clinical Research Center for Gastroenterology, Office of Science and Technology of Chongqing  No. 2 Xingai road Chongqing, Yubei 401147 China"},{"name":"Chongqing Institute for Brain and Intelligence, Guangyang Bay Laboratory  Chongqing 400064 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3547-0462","authenticated-orcid":false,"given":"Malcolm","family":"Xing","sequence":"additional","affiliation":[{"name":"Department of Mechanical Engineering University of Manitoba  Winnipeg Manitoba MB R3T 2N2 Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaoqiang","family":"Fan","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Xinqiao Hospital Army Medical University  NO.183, Xinqiao Street Chongqing 400037 China"},{"name":"Chongqing Municipality Clinical Research Center for Gastroenterology, Office of Science and Technology of Chongqing  No. 2 Xingai road Chongqing, Yubei 401147 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,8,8]]},"reference":[{"key":"e_1_2_8_1_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2020.108899"},{"key":"e_1_2_8_1_2","author":"Hu B.","year":"2017","journal-title":"Gastrointest. 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