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Photothermal therapy (PTT) at mild temperature presents a promising alternative to traditional antibiotics due to its biological safety and ability to circumvent drug resistance. However, the efficacy of mild PTT is limited by bacterial thermotolerance. Herein, a nanocomposite, BP@Mn\u2010NC, comprising black phosphorus nanosheets and a manganese\u2010based nanozyme (Mn\u2010NZ) is developed, which possesses both photothermal and catalytic properties. Mn\u2010NZ imparts glucose oxidase\u2010 and peroxidase\u2010like properties to BP@Mn\u2010NC, generating reactive oxygen species (ROS) that induce lipid peroxidation and malondialdehyde accumulation across the bacterial cell membrane. This process disrupts unprotected respiratory chain complexes exposed on the bacterial cell membrane, leading to a reduction in the intracellular adenosine triphosphate (ATP) content. Consequently, mild PTT mediated by BP@Mn\u2010NC effectively eliminates MDR infections by specifically impairing bacterial thermotolerance because of the dependence of bacterial heat shock proteins (HSPs) on ATP molecules for their proper functioning. This study paves the way for the development of a novel photothermal strategy to eradicate MDR pathogens, which targets bacterial HSPs through ROS\u2010mediated inhibition of bacterial respiratory chain activity.<\/jats:p>","DOI":"10.1002\/advs.202303911","type":"journal-article","created":{"date-parts":[[2023,9,12]],"date-time":"2023-09-12T10:59:44Z","timestamp":1694516384000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":79,"title":["Black Phosphorus\/MnO\n                    <sub>2<\/sub>\n                    Nanocomposite Disrupting Bacterial Thermotolerance for Efficient Mild\u2010Temperature Photothermal Therapy"],"prefix":"10.1002","volume":"10","author":[{"given":"Feng","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Orthopedics Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine School of Biomedical Engineering Shanghai Jiao Tong University  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