{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T18:01:51Z","timestamp":1791050511752,"version":"4.1.0"},"reference-count":57,"publisher":"Wiley","issue":"33","license":[{"start":{"date-parts":[[2023,10,9]],"date-time":"2023-10-09T00:00:00Z","timestamp":1696809600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82171885"],"award-info":[{"award-number":["82171885"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Ulcerative colitis (UC) is a chronic inflammatory bowel disease mainly involving the colon and rectum, which features recurrent mucosal inflammation. The excessive production of reactive oxygen species (ROS) is a trigger for pathological changes such as cell apoptosis and disordered immune microenvironments, which are crucial for the progression of UC and can be a promising therapeutic target. Nowadays, the development of targeted therapeutic strategies for UC is still in its infancy. Thus, developing effective therapies based on ROS scavenging and elucidating their molecular pathways are urgently needed. Herein, a biomimetic nanoformulation (Pd@M) with cubic palladium (Pd) as the core and macrophage\u2010derived extracellular vesicles (MEVs) as the shell is synthesized for the treatment of UC. These Pd@M nanoformulations exhibit multienzyme\u2010like activities for effective ROS scavenging, excellent targeting ability as well as good biocompatibility. It is verified that Pd@M can regulate the polarization state of macrophages by inhibiting glycolysis, and decrease neutrophil infiltration and recruitment. In this way, the colonic inflammatory and immune microenvironment is remodeled, and apoptosis is prevented, ultimately improving colonic mucosal barrier function and alleviating colitis in the mouse model. This finding provides a promising alternative option for the treatment of UC patients.<\/jats:p>","DOI":"10.1002\/advs.202304002","type":"journal-article","created":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T21:36:04Z","timestamp":1697060164000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":47,"title":["Macrophage\u2010Derived Extracellular Vesicles\u2010Coated Palladium Nanoformulations Modulate Inflammatory and Immune Homeostasis for Targeting Therapy of Ulcerative Colitis"],"prefix":"10.1002","volume":"10","author":[{"given":"Jiahui","family":"Cheng","sequence":"first","affiliation":[{"name":"Department of Radiology Renji Hospital School of Medicine Shanghai Jiao Tong University  No. 160, Pujian Road, Pudong District Shanghai 200127 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiming","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Radiology Renji Hospital School of Medicine Shanghai Jiao Tong University  No. 160, Pujian Road, Pudong District Shanghai 200127 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Radiology National Children's Medical Center Children's Hospital of Fudan University  No. 399, Wanyuan Road, Minhang District Shanghai 201102 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenxian","family":"Du","sequence":"additional","affiliation":[{"name":"Institute of Diagnostic and Interventional Radiology Shanghai Sixth People's Hospital School of Medicine Shanghai Jiao Tong University  No. 600, Yishan Road, Xuhui District Shanghai 200233 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Institute of Diagnostic and Interventional Radiology Shanghai Sixth People's Hospital School of Medicine Shanghai Jiao Tong University  No. 600, Yishan Road, Xuhui District Shanghai 200233 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rifeng","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Cardiology Zhongshan Hospital Fudan University  No. 180, Fenglin Road, Xuhui District Shanghai 200025 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinxin","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Radiology Renji Hospital School of Medicine Shanghai Jiao Tong University  No. 160, Pujian Road, Pudong District Shanghai 200127 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yujie","family":"Chen","sequence":"additional","affiliation":[{"name":"Morphology and Spatial Multi\u2010Omics Technology Platform Shanghai Institute of Nutrition and Health Chinese Academy of Sciences  No. 320, Yueyang Road Shanghai 200031 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lixian","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Ultrasound in Medicine Shanghai Sixth People's Hospital School of Medicine Shanghai Jiao Tong University  No. 600, Yishan Road, Xuhui District Shanghai 200233 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyang","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Food Science and Technology School of Agriculture and Biology Shanghai Jiao Tong University  No. 800, Dongchuan Road, Minhang District Shanghai 200240 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9476-3073","authenticated-orcid":false,"given":"Bo","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Radiology Renji Hospital School of Medicine Shanghai Jiao Tong University  No. 160, Pujian Road, Pudong District Shanghai 200127 China"},{"name":"Key Laboratory of Anesthesiology (Shanghai Jiao Tong University) Ministry of Education  No. 160, Pujian Road, Pudong District Shanghai 200127 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Radiology Renji Hospital School of Medicine Shanghai Jiao Tong University  No. 160, Pujian Road, Pudong District Shanghai 200127 China"},{"name":"College of Health Science and Technology Shanghai Jiao Tong University School of Medicine  No. 227, Chongqingnan Road Huangpu District Shanghai 200025 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,10,9]]},"reference":[{"key":"e_1_2_8_1_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1102942"},{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-020-0205-x"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.5694\/mja17.01001"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2009.727"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40257-017-0296-7"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/00365521.2021.1998601"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2012.5149"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.25074"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41565-023-01346-x"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2023.01.015"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202212566"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abb2695"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mattod.2022.11.007"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1039\/C8CS00718G"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1039\/C5NR05675F"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.6b06297"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.2c03422"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2015.186"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI59643"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature12034"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/cr.2015.68"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2017.7420"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2021.105796"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.649463"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2010.06.022"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1113\/JP280572"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.201900605"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.1c21700"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202108817"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.201500129"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.6b03148"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2021012295"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.nanolett.8b03439"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri1312"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1159\/000047804"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2017.01.033"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20235898"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.79422"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmet.2018.11.013"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.30536"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-10-249540"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2018-11-844530"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.abl7482"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2017.02.004"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1011165"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2011.03.054"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2020.07.007"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcis.2021.10.129"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202106265"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1038\/nnano.2012.212"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1501537"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-018-1095-7"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1038\/labinvest.3700289"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI44631"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.1093\/ibd\/izab239"},{"key":"e_1_2_8_56_1","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.1A0314-170R"},{"key":"e_1_2_8_57_1","first-page":"1297","volume":"21","author":"Lissner D.","year":"2015","journal-title":"Inflamm. Bowel Dis."}],"container-title":["Advanced Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/advs.202304002","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T17:14:37Z","timestamp":1759770877000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/advs.202304002"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10,9]]},"references-count":57,"journal-issue":{"issue":"33","published-print":{"date-parts":[[2023,11]]}},"alternative-id":["10.1002\/advs.202304002"],"URL":"https:\/\/doi.org\/10.1002\/advs.202304002","archive":["Portico"],"relation":{},"ISSN":["2198-3844","2198-3844"],"issn-type":[{"value":"2198-3844","type":"print"},{"value":"2198-3844","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,10,9]]},"assertion":[{"value":"2023-06-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-10-09","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"2304002"}}