{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T17:01:00Z","timestamp":1793466060556,"version":"4.5.0"},"reference-count":53,"publisher":"Wiley","issue":"29","license":[{"start":{"date-parts":[[2023,8,9]],"date-time":"2023-08-09T00:00:00Z","timestamp":1691539200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004607","name":"Natural Science Foundation of Guangxi Province","doi-asserted-by":"publisher","award":["2023GXNSFBA026137"],"award-info":[{"award-number":["2023GXNSFBA026137"]}],"id":[{"id":"10.13039\/501100004607","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Despite advances in cancer therapy, the existence of self\u2010renewing cancer stem cells (CSC) can lead to tumor recurrence and radiation resistance, resulting in treatment failure and high mortality in patients. To address this issue, a near\u2010infrared (NIR) laser\u2010induced synergistic therapeutic platform has been developed by incorporating aggregation\u2010induced emission (AIE)\u2010active phototheranostic agents and sulfur dioxide (SO\n                    <jats:sub>2<\/jats:sub>\n                    ) prodrug into a biocompatible hydrogel, namely TBH, to suppress malignant CSC growth. Outstanding hydroxyl radical (\u00b7OH) generation and photothermal effect of the AIE phototheranostic agent actualizes Type I photodynamic therapy (PDT) and photothermal therapy through 660\u00a0nm NIR laser irradiation. Meanwhile, a large amount of SO\n                    <jats:sub>2<\/jats:sub>\n                    is released from the SO\n                    <jats:sub>2<\/jats:sub>\n                    prodrug in thermo\u2010sensitive TBH gel, which depletes upregulated glutathione in CSC and consequentially promotes \u00b7OH generation for PDT enhancement. Thus, the resulting TBH hydrogel can diminish CSC under 660\u00a0nm laser irradiation and finally restrain tumor recurrence after radiotherapy (RT). In comparison, the tumor in the mice that were only treated with RT relapsed rapidly. These findings reveal a double\u2010boosting \u00b7OH generation protocol, and the synergistic combination of AIE\u2010mediated PDT and gas therapy provides a novel strategy for inhibiting CSC growth and cancer recurrence after RT, which presents great potential for clinical treatment.\n                  <\/jats:p>","DOI":"10.1002\/advs.202304042","type":"journal-article","created":{"date-parts":[[2023,8,9]],"date-time":"2023-08-09T23:42:29Z","timestamp":1691624549000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":53,"title":["Photothermal\u2010Triggered Sulfur Oxide Gas Therapy Augments Type I Photodynamic Therapy for Potentiating Cancer Stem Cell Ablation and Inhibiting Radioresistant Tumor Recurrence"],"prefix":"10.1002","volume":"10","author":[{"given":"Tianfu","family":"Zhang","sequence":"first","affiliation":[{"name":"School of Biomedical Engineering Guangzhou Medical University  Guangzhou 510182 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