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However, technologies that can simultaneously prevent CTCs and TDEs from reaching distant organs have not been thoroughly developed until now. Here, inspired by hemoperfusion, a pro\u2010metastatic derivative eliminator (PMDE) is developed for the removal of both CTCs and TDEs from the peripheral blood, which also inhibits their biodistribution in distant organs. This device is designed with a dual antibody\u2010modified immunosorbent filled into a capture column that draws peripheral blood out of the body to flow through the column to specifically capture CTCs and TDEs, followed by retransfusing the purified blood into the body. The PMDE can efficiently remove CTCs and TDEs from the peripheral blood and has excellent biocompatibility. Interestingly, the PMDE device can significantly inhibit the biodistribution of CTCs and TDEs in the lung and liver by scavenging them. This work provides a new perspective on anti\u2010metastatic therapy and has broad prospects in clinical applications to prevent metastasis and recurrence.<\/jats:p>","DOI":"10.1002\/advs.202304287","type":"journal-article","created":{"date-parts":[[2023,10,23]],"date-time":"2023-10-23T00:00:20Z","timestamp":1698019220000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["A Pro\u2010Metastatic Derivatives Eliminator for In Vivo Dual\u2010Removal of Circulating Tumor Cells and Tumor\u2010Derived Exosomes Impedes their Biodistribution into Distant Organs"],"prefix":"10.1002","volume":"10","author":[{"given":"Ying","family":"Sun","sequence":"first","affiliation":[{"name":"State Key Laboratory of Natural Medicines China Pharmaceutical University  Nanjing 210009 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Xing","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Natural Medicines China Pharmaceutical University  Nanjing 210009 China"},{"name":"Jiangsu Key Laboratory of Druggability of Biopharmaceuticals China Pharmaceutical University  Nanjing 210009 China"},{"name":"Jiangsu Key Laboratory of Drug Discovery for Metabolic Diseases China Pharmaceutical University  Nanjing 210009 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Luo","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Natural Medicines China Pharmaceutical University  Nanjing 210009 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming\u2010Tao","family":"Yu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Natural Medicines China Pharmaceutical University  Nanjing 210009 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao\u2010Jie","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Natural Medicines China Pharmaceutical University  Nanjing 210009 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Natural Medicines China Pharmaceutical University  Nanjing 210009 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tian\u2010Jiao","family":"Zhou","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Natural Medicines China Pharmaceutical University  Nanjing 210009 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1620-1777","authenticated-orcid":false,"given":"Hu\u2010Lin","family":"Jiang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Natural Medicines China Pharmaceutical University  Nanjing 210009 China"},{"name":"Jiangsu Key Laboratory of Druggability of Biopharmaceuticals China Pharmaceutical University  Nanjing 210009 China"},{"name":"Jiangsu Key Laboratory of Drug Discovery for Metabolic Diseases China Pharmaceutical University  Nanjing 210009 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,10,22]]},"reference":[{"key":"e_1_2_7_1_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1203543"},{"key":"e_1_2_7_1_2","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21660"},{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsb.2020.11.024"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature17038"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-18-1285"},{"key":"e_1_2_7_3_3","doi-asserted-by":"publisher","DOI":"10.1126\/science.1228522"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.1c09807"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s43018-021-00272-y"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature15756"},{"key":"e_1_2_7_5_3","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2021.09.002"},{"key":"e_1_2_7_5_4","doi-asserted-by":"publisher","DOI":"10.1002\/jev2.12168"},{"key":"e_1_2_7_5_5","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-28438-x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2016.09.011"},{"key":"e_1_2_7_7_1","first-page":"2281","volume":"40","author":"Hart I. 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