{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T22:35:40Z","timestamp":1791930940445,"version":"4.3.4"},"reference-count":58,"publisher":"Wiley","issue":"20","license":[{"start":{"date-parts":[[2024,3,27]],"date-time":"2024-03-27T00:00:00Z","timestamp":1711497600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,3,27]],"date-time":"2024-03-27T00:00:00Z","timestamp":1711497600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2018YFA0800803"],"award-info":[{"award-number":["2018YFA0800803"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32230045"],"award-info":[{"award-number":["32230045"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Chronic atrophic gastritis (AG) is initiated mainly by\n                    <jats:italic>Helicobacter pylori<\/jats:italic>\n                    infection, which may progress to stomach cancer following the Correa's cascade. The current treatment regimen is\n                    <jats:italic>H. pylori<\/jats:italic>\n                    eradication, yet evidence is lacking that this treatment is effective on later stages of AG especially gastric gland atrophy. Here, using AG mouse model, patient samples, gastric organoids, and lineage tracing, this study unraveled gastric stem cell (GSC) defect as a crucial pathogenic factor in AG in mouse and human. Moreover, a natural peptide is isolated from a traditional Chinese medicine that activated GSCs to regenerate gastric epithelia in experimental AG models and revitalized the atrophic gastric organoids derived from patients. It is further shown that the peptide exerts its functions by stabilizing the EGF\u2010EGFR complex and specifically activating the downstream ERK and Stat1 signaling. Overall, these findings advance the understanding of AG pathogenesis and open a new avenue for AG treatment.\n                  <\/jats:p>","DOI":"10.1002\/advs.202304326","type":"journal-article","created":{"date-parts":[[2024,3,28]],"date-time":"2024-03-28T01:42:45Z","timestamp":1711590165000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["A Natural Peptide from A Traditional Chinese Medicine Has the Potential to Treat Chronic Atrophic Gastritis by Activating Gastric Stem Cells"],"prefix":"10.1002","volume":"11","author":[{"given":"Ke","family":"Li","sequence":"first","affiliation":[{"name":"Institute of Traditional Chinese Medicine and Stem Cell Research College of Basic Medical Sciences Chengdu University of Traditional Chinese Medicine  Chengdu 611137 China"},{"name":"Bio\u2010X Institutes Shanghai Jiao Tong University  Shanghai 200240 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiuying","family":"Ma","sequence":"additional","affiliation":[{"name":"Sichuan Engineering Research Center for Medicinal Animals Sichuan Good Doctor Panxi Pharmaceutical Co., Ltd  Chengdu 610000 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zihao","family":"Li","sequence":"additional","affiliation":[{"name":"Bio\u2010X Institutes Shanghai Jiao Tong University  Shanghai 200240 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya","family":"Liu","sequence":"additional","affiliation":[{"name":"Institute of Traditional Chinese Medicine and Stem Cell Research College of Basic Medical Sciences Chengdu University of Traditional Chinese Medicine  Chengdu 611137 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guiyan","family":"Shen","sequence":"additional","affiliation":[{"name":"Institute of Traditional Chinese Medicine and Stem Cell Research College of Basic Medical Sciences Chengdu University of Traditional Chinese Medicine  Chengdu 611137 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zecheng","family":"Luo","sequence":"additional","affiliation":[{"name":"Institute of Traditional Chinese Medicine and Stem Cell Research College of Basic Medical Sciences Chengdu University of Traditional Chinese Medicine  Chengdu 611137 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong","family":"Wang","sequence":"additional","affiliation":[{"name":"Institute of Traditional Chinese Medicine and Stem Cell Research College of Basic Medical Sciences Chengdu University of Traditional Chinese Medicine  Chengdu 611137 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Xia","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology Key Laboratory of Cell Differentiation and Apoptosis of the Chinese Ministry of Education Shanghai Jiao Tong University School of Medicine  Shanghai 200025 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengting","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Ruijin Hospital School of Medicine Shanghai Jiao Tong University  Shanghai 200025 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Tian","sequence":"additional","affiliation":[{"name":"Department of Burn Ruijin Hospital School of Medicine Shanghai Jiao Tong University  Shanghai 200025 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huijuan","family":"Liu","sequence":"additional","affiliation":[{"name":"Bio\u2010X Institutes Shanghai Jiao Tong University  Shanghai 200240 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Funeng","family":"Geng","sequence":"additional","affiliation":[{"name":"Sichuan Engineering Research Center for Medicinal Animals Sichuan Good Doctor Panxi Pharmaceutical Co., Ltd  Chengdu 610000 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3913-1062","authenticated-orcid":false,"given":"Baojie","family":"Li","sequence":"additional","affiliation":[{"name":"Institute of Traditional Chinese Medicine and Stem Cell Research College of Basic Medical Sciences Chengdu University of Traditional Chinese Medicine  Chengdu 611137 China"},{"name":"Bio\u2010X Institutes Shanghai Jiao Tong University  Shanghai 200240 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,3,27]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-pathol-032520-024949"},{"key":"e_1_2_9_1_2","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2022-328965"},{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11894-020-00775-1"},{"key":"e_1_2_9_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2013.101"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2016-311685"},{"key":"e_1_2_9_3_2","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2019-319696"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1100959108"},{"key":"e_1_2_9_4_2","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aau6547"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmgh.2017.12.012"},{"key":"e_1_2_9_5_2","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00016.2019"},{"key":"e_1_2_9_5_3","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2011-300539"},{"key":"e_1_2_9_5_4","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20182325"},{"key":"e_1_2_9_6_1","first-page":"6735","volume":"52","author":"Correa P.","year":"1992","journal-title":"Cancer Res."},{"key":"e_1_2_9_6_2","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2019-319002"},{"key":"e_1_2_9_6_3","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2017-315318"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10120-015-0462-7"},{"key":"e_1_2_9_7_2","first-page":"414","volume":"30","author":"Rokkas T.","year":"2017","journal-title":"Ann Gastroenterol"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2017-314605"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2021.05.012"},{"key":"e_1_2_9_9_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-physiol-021119-034500"},{"key":"e_1_2_9_9_3","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-14058-5"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41556-019-0339-9"},{"key":"e_1_2_9_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2013.09.008"},{"key":"e_1_2_9_10_3","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2020.571536"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2011.09.001"},{"key":"e_1_2_9_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2009.11.013"},{"key":"e_1_2_9_11_3","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2014-307190"},{"key":"e_1_2_9_11_4","doi-asserted-by":"publisher","DOI":"10.1038\/nature23642"},{"key":"e_1_2_9_11_5","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-1973-x"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2015.02.049"},{"key":"e_1_2_9_12_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1903798116"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-29176-w"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/jme\/tjz082"},{"key":"e_1_2_9_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2016.10.021"},{"key":"e_1_2_9_14_3","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0155304"},{"key":"e_1_2_9_14_4","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2018.00944"},{"key":"e_1_2_9_14_5","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2017.06.007"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2008.12.059"},{"key":"e_1_2_9_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2012.04.013"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/9012929"},{"key":"e_1_2_9_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2020.117456"},{"key":"e_1_2_9_16_3","doi-asserted-by":"publisher","DOI":"10.1007\/s11655-015-2114-5"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaf9414"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41556-021-00639-4"},{"key":"e_1_2_9_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.04.052"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41568-018-0090-8"},{"key":"e_1_2_9_19_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20161427"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djx014"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0898-6568(03)00056-1"},{"key":"e_1_2_9_21_2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-06-2439"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.5851\/kosfa.2022.e46"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2212736119"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2019.04.052"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.E18-08-0488"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.1999.01432.x"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2021.04.062"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-15-2971"},{"key":"e_1_2_9_28_2","doi-asserted-by":"publisher","DOI":"10.1038\/cdd.2016.115"}],"container-title":["Advanced Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/advs.202304326","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/advs.202304326","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/advs.202304326","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T15:04:25Z","timestamp":1777561465000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/advs.202304326"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3,27]]},"references-count":58,"journal-issue":{"issue":"20","published-print":{"date-parts":[[2024,5]]}},"alternative-id":["10.1002\/advs.202304326"],"URL":"https:\/\/doi.org\/10.1002\/advs.202304326","archive":["Portico"],"relation":{},"ISSN":["2198-3844","2198-3844"],"issn-type":[{"value":"2198-3844","type":"print"},{"value":"2198-3844","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,3,27]]},"assertion":[{"value":"2023-06-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-03-27","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"2304326"}}