{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T01:55:11Z","timestamp":1793066111866,"version":"4.5.0"},"reference-count":34,"publisher":"Wiley","issue":"16","license":[{"start":{"date-parts":[[2024,2,21]],"date-time":"2024-02-21T00:00:00Z","timestamp":1708473600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["2022ZFJH003"],"award-info":[{"award-number":["2022ZFJH003"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012165","name":"Key Technologies Research and Development Program","doi-asserted-by":"publisher","award":["2017C03051"],"award-info":[{"award-number":["2017C03051"]}],"id":[{"id":"10.13039\/501100012165","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This work aims to explore the long\u2010term prognosis of hepatitis B virus\u2010related acute\u2010on\u2010chronic liver failure (HBV\u2010ACLF). In this prospective study, eligible inpatients with HBV\u2010ACLF are enrolled and followed up from December 2012 to February 2023, for clinical events, laboratory tests at least every 6 months. Overall, the survival rates at 28 days, 90 days, 1 year, 5 years, and 8 years are 64.7%, 48.8%, 46.1%, 43.8%, and 42.2%, respectively. Among the 8\u2010year mortality and liver transplant cases, ACLF survivors (who survived over 90 days) accounted for 7.8% (9\/115). Among 101 patients who survived for more than 90 days, 97.9% of patients achieve virologic response at 1 year. For HBeAg\u2010positive patients, the HBeAg seroconversion are 25.5%, 63.6%, and 76.9% at 1, 5, and 8 years, respectively. Alanine aminotransferase, aspartate aminotransferase, total bilirubin, INR, white blood cell count, and albumin levels gradually improve within the first year. Fibrosis biomarkers APRI, FIB\u20104 and Chitinase\u20103\u2010like protein 1 (CHI3L1) levels decreases within the first 5 years. The Cox proportional hazards regression reveal that high total bilirubin (HR = 1.008, <jats:italic>p<\/jats:italic> = 0.021) is the independent risk factor for 8\u2010year survival of ALCF survivors. The 90\u2010day period following of HBV\u2010ACLF represented a critical juncture for long\u2010term prognosis, revealing favorable outcomes beyond this timeframe.<\/jats:p>","DOI":"10.1002\/advs.202304381","type":"journal-article","created":{"date-parts":[[2024,2,21]],"date-time":"2024-02-21T05:03:16Z","timestamp":1708491796000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["The 90\u2010Day Survival Threshold: A Pivotal Determinant of Long\u2010Term Prognosis in HBV\u2010ACLF Patients \u2013 Insights from a Prospective Longitudinal Cohort Study"],"prefix":"10.1002","volume":"11","author":[{"given":"Lanlan","family":"Xiao","sequence":"first","affiliation":[{"name":"State Key Laboratory for Diagnosis and Treatment of Infectious Diseases National Clinical Research Center for Infectious Diseases National Medical Center for Infectious Diseases Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases The First Affiliated Hospital Zhejiang University School of Medicine  79 Qingchun Rd. Hangzhou City 310003 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiajia","family":"Chen","sequence":"additional","affiliation":[{"name":"State Key Laboratory for Diagnosis and Treatment of Infectious Diseases National Clinical Research Center for Infectious Diseases National Medical Center for Infectious Diseases Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases The First Affiliated Hospital Zhejiang University School of Medicine  79 Qingchun Rd. 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Hangzhou City 310003 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhangya","family":"Pu","sequence":"additional","affiliation":[{"name":"State Key Laboratory for Diagnosis and Treatment of Infectious Diseases National Clinical Research Center for Infectious Diseases National Medical Center for Infectious Diseases Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases The First Affiliated Hospital Zhejiang University School of Medicine  79 Qingchun Rd. 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