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Cell transplantation is a promising strategy to facilitate nerve restoration in SCI. In this research, a pro\u2010regeneration system is developed, namely miR\u201026a@SPIONs\u2010OECs, for olfactory ensheathing cells (OECs), a preferred choice for promoting nerve regeneration in SCI patients. These entities show high responsiveness to external magnetic fields (MF), leading to synergistic multimodal cues to enhance nerve regeneration. First, an MF stimulates miR\u201026a@SPIONs\u2010OECs to release extracellular vesicles (EVs) rich in miR\u201026a. This encourages axon growth by inhibiting PTEN and GSK\u20103\u03b2 signaling pathways in neurons. Second, miR\u201026a@SPIONs\u2010OECs exhibit a tendency to migrate and orientate along the direction of the MF, thereby potentially facilitating neuronal reconnection through directional neurite elongation. Third, miR\u201026a\u2010enriched EVs from miR\u201026a@SPIONs\u2010OECs can interact with host astrocytes, thereby diminishing inhibitory cues for neurite growth. In a rat model of SCI, the miR\u201026a@SPIONs\u2010OECs system led to significantly improved morphological and motor function recovery. 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