{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:24:38Z","timestamp":1786976678199,"version":"build-2736575974"},"reference-count":56,"publisher":"Wiley","issue":"16","license":[{"start":{"date-parts":[[2024,2,22]],"date-time":"2024-02-22T00:00:00Z","timestamp":1708560000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82030081"],"award-info":[{"award-number":["82030081"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2021YFA1300601"],"award-info":[{"award-number":["2021YFA1300601"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cells are critical for host antitumor responses, whereas persistent antigenic stimulation and excessive inflammatory signals lead to T cell dysfunction or exhaustion. Increasing early memory T cells can improve T cell persistence and empower T cell\u2010mediated tumor eradication, especially for adoptive cancer immunotherapy. Here, it is reported that tumor\u2010associated monocytes (TAMos) are highly correlated with the accumulation of CD8\n                    <jats:sup>+<\/jats:sup>\n                    memory T cells in human cancers. Further analysis identifies that TAMos selectively reprogram CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cells into T central memory\u2010like (T\n                    <jats:sub>CM<\/jats:sub>\n                    \u2010like) cells with enhanced recall responses. L\u2010NMMA, a pan nitric oxide synthase inhibitor, can mitigate TAMo\u2010mediated inhibition of T cell proliferation without affecting T\n                    <jats:sub>CM<\/jats:sub>\n                    \u2010like cell generation. Moreover, the modified T cells by TAMo exposure and L\u2010NMMA treatment exhibit long\u2010term persistence and elicit superior antitumor effects in vivo. Mechanistically, the transmembrane protein CD300LG is involved in TAMo\u2010mediated T\n                    <jats:sub>CM<\/jats:sub>\n                    \u2010like cell polarization in a cell\u2010cell contact\u2010dependent manner. Thus, the terminally differentiated TAMo subset (CD300LG\n                    <jats:sup>high<\/jats:sup>\n                    ACE\n                    <jats:sup>low<\/jats:sup>\n                    ) mainly contributes to T\n                    <jats:sub>CM<\/jats:sub>\n                    \u2010like cell development. Taken together, these findings establish the significance of TAMos in boosting T\u2010cell antitumor immunity.\n                  <\/jats:p>","DOI":"10.1002\/advs.202304501","type":"journal-article","created":{"date-parts":[[2024,2,22]],"date-time":"2024-02-22T11:33:03Z","timestamp":1708601583000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Tumor\u2010Associated Monocytes Reprogram CD8\n                    <sup>+<\/sup>\n                    T Cells into Central Memory\u2010Like Cells with Potent Antitumor Effects"],"prefix":"10.1002","volume":"11","author":[{"given":"Zeliang","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Pathology, Institute of Systems Biomedicine School of Basic Medical Sciences Beijing Key Laboratory of Tumor Systems Biology Peking University Health Science Center  Beijing 100191 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