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In this study, single\u2010cell RNA sequencing (scRNA\u2010seq) is employed to investigate the synovial cell composition of DOA. A significant enrichment of activated macrophages within eight distinct synovial cell clusters is found in DOA synovium. Moreover, it is demonstrated that increased glycolysis in FLSs is a key driver for DOA patients\u2019 synovial macrophage infiltration and polarization. In addition, the yes\u2010associated protein 1 (YAP1)\/thioredoxin\u2010interacting protein (TXNIP) signaling axis is demonstrated to play a crucial role in regulating glucose transporter 1 (GLUT1)\u2010dependent glycolysis in FLSs, thereby controlling the expression of a series of adhesion molecules such as intercellular adhesion molecule\u20101 (ICAM\u20101) which may subsequently fine\u2010tune the infiltration of M1\u2010polarized synovial macrophages in DOA patients and\n                    <jats:italic>db\/db<\/jats:italic>\n                    diabetic OA mice. For treatment, M1 macrophage membrane\u2010camouflaged Verteporfin (Vt)\u2010loaded PLGA nanoparticles (MVPs) are developed to ameliorate DOA progression by regulating the YAP1\/TXNIP signaling axis, thus suppressing the synovial glycolysis and the infiltration of M1\u2010polarized macrophages. The results provide several novel insights into the pathogenesis of DOA and offer a promising treatment approach for DOA.\n                  <\/jats:p>","DOI":"10.1002\/advs.202304617","type":"journal-article","created":{"date-parts":[[2023,12,3]],"date-time":"2023-12-03T22:29:56Z","timestamp":1701642596000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":86,"title":["Targeting YAP1\u2010regulated Glycolysis in Fibroblast\u2010Like Synoviocytes Impairs Macrophage Infiltration to Ameliorate Diabetic Osteoarthritis Progression"],"prefix":"10.1002","volume":"11","author":[{"given":"Jie","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Bone and Joint Surgery the First Affiliated Hospital of Jinan University Key Laboratory of Regenerative Medicine of Ministry of Education Jinan University  Guangzhou Guangdong 510630 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