{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T13:54:21Z","timestamp":1791726861237,"version":"4.3.4"},"reference-count":57,"publisher":"Wiley","issue":"34","license":[{"start":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T00:00:00Z","timestamp":1696982400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82200213"],"award-info":[{"award-number":["82200213"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81970146"],"award-info":[{"award-number":["81970146"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82170185"],"award-info":[{"award-number":["82170185"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Chronic lymphocytic leukemia (CLL) is a hematological malignancy with high metabolic heterogeneity. N6\u2010methyladenosine (m6A) modification plays an important role in metabolism through regulating circular RNAs (circRNAs). However, the underlying mechanism is not yet fully understood in CLL. Herein, an m6A scoring system and an m6A\u2010related circRNA prognostic signature are established, and circTET2 as a potential prognostic biomarker for CLL is identified. The level of m6A modification is found to affect the transport of circTET2 out of the nucleus. By interacting with the RNA\u2010binding protein (RBP) heterogeneous nuclear ribonucleoprotein C (HNRNPC), circTET2 regulates the stability of CPT1A and participates in the lipid metabolism and proliferation of CLL cells through mTORC1 signaling pathway. The mTOR inhibitor dactolisib and FAO inhibitor perhexiline exert a synergistic effect on CLL cells. In addition, the biogenesis of circTET2 can be affected by the splicing process and the RBPs RBMX and YTHDC1. CP028, a splicing inhibitor, modulates the expression of circTET2 and shows pronounced inhibitory effects. In summary, circTET2 plays an important role in the modulation of lipid metabolism and cell proliferation in CLL. This study demonstrates the clinical value of circTET2 as a prognostic indicator as well as provides novel insights in targeting treatment for CLL.<\/jats:p>","DOI":"10.1002\/advs.202304895","type":"journal-article","created":{"date-parts":[[2023,10,12]],"date-time":"2023-10-12T02:11:08Z","timestamp":1697076668000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":51,"title":["m6A\u2010Modified circTET2 Interacting with HNRNPC Regulates Fatty Acid Oxidation to Promote the Proliferation of Chronic Lymphocytic Leukemia"],"prefix":"10.1002","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8607-7858","authenticated-orcid":false,"given":"Zijuan","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Hematology the First Affiliated Hospital of Nanjing Medical University Jiangsu Province Hospital Nanjing Medical University  Nanjing 210029 China"},{"name":"Key Laboratory of Hematology of Nanjing Medical University  Nanjing 210029 China"},{"name":"Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment Collaborative Innovation Center for Personalized Cancer Medicine Nanjing Medical University  Nanjing 210029 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoling","family":"Zuo","sequence":"additional","affiliation":[{"name":"Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment Collaborative Innovation Center for Personalized Cancer Medicine Nanjing Medical University  Nanjing 210029 China"},{"name":"Anqing First People's Hospital of Anhui Medical University Anqing First People's Hospital of Anhui Province  Anqing 246004 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Hematology the First Affiliated Hospital of Nanjing Medical University Jiangsu Province Hospital Nanjing Medical University  Nanjing 210029 China"},{"name":"Key Laboratory of Hematology of Nanjing Medical University  Nanjing 210029 China"},{"name":"Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment Collaborative Innovation Center for Personalized Cancer Medicine Nanjing Medical University  Nanjing 210029 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongle","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Hematology the First Affiliated Hospital of Nanjing Medical University Jiangsu Province Hospital Nanjing Medical University  Nanjing 210029 China"},{"name":"Key Laboratory of Hematology of Nanjing Medical University  Nanjing 210029 China"},{"name":"Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment Collaborative Innovation Center for Personalized Cancer Medicine Nanjing Medical University  Nanjing 210029 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renfu","family":"Gui","sequence":"additional","affiliation":[{"name":"Department of Hematology the First Affiliated Hospital of Nanjing Medical University Jiangsu Province Hospital Nanjing Medical University  Nanjing 210029 China"},{"name":"Key Laboratory of Hematology of Nanjing Medical University  Nanjing 210029 China"},{"name":"Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment Collaborative Innovation Center for Personalized Cancer Medicine Nanjing Medical University  Nanjing 210029 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiayan","family":"Leng","sequence":"additional","affiliation":[{"name":"Department of Hematology Affiliated People's Hospital of Jiangsu University  Zhenjiang 212002 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haorui","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Hematology the First Affiliated Hospital of Nanjing Medical University Jiangsu Province Hospital Nanjing Medical University  Nanjing 210029 China"},{"name":"Key Laboratory of Hematology of Nanjing Medical University  Nanjing 210029 China"},{"name":"Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment Collaborative Innovation Center for Personalized Cancer Medicine Nanjing Medical University  Nanjing 210029 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bihui","family":"Pan","sequence":"additional","affiliation":[{"name":"Department of Hematology the First Affiliated Hospital of Nanjing Medical University Jiangsu Province Hospital Nanjing Medical University  Nanjing 210029 China"},{"name":"Key Laboratory of Hematology of Nanjing Medical University  Nanjing 210029 China"},{"name":"Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment Collaborative Innovation Center for Personalized Cancer Medicine Nanjing Medical University  Nanjing 210029 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Fan","sequence":"additional","affiliation":[{"name":"Department of Hematology the First Affiliated Hospital of Nanjing Medical University Jiangsu Province Hospital Nanjing Medical University  Nanjing 210029 China"},{"name":"Key Laboratory of Hematology of Nanjing Medical University  Nanjing 210029 China"},{"name":"Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment Collaborative Innovation Center for Personalized Cancer Medicine Nanjing Medical University  Nanjing 210029 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianyong","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Hematology the First Affiliated Hospital of Nanjing Medical University Jiangsu Province Hospital Nanjing Medical University  Nanjing 210029 China"},{"name":"Key Laboratory of Hematology of Nanjing Medical University  Nanjing 210029 China"},{"name":"Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment Collaborative Innovation Center for Personalized Cancer Medicine Nanjing Medical University  Nanjing 210029 China"},{"name":"National Clinical Research Center for Hematologic Diseases the First Affiliated Hospital of Soochow University  Suzhou 215000 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0297-3052","authenticated-orcid":false,"given":"Hui","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of Hematology the First Affiliated Hospital of Nanjing Medical University Jiangsu Province Hospital Nanjing Medical University  Nanjing 210029 China"},{"name":"Key Laboratory of Hematology of Nanjing Medical University  Nanjing 210029 China"},{"name":"Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment Collaborative Innovation Center for Personalized Cancer Medicine Nanjing Medical University  Nanjing 210029 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,10,11]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmolb.2021.763902"},{"key":"e_1_2_9_1_2","doi-asserted-by":"publisher","DOI":"10.1186\/s43556-020-00012-1"},{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.26367"},{"key":"e_1_2_9_2_2","doi-asserted-by":"publisher","DOI":"10.1186\/s40164-022-00292-z"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1158\/1541-7786.MCR-14-0412"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI141529"},{"key":"e_1_2_9_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2021.06.004"},{"key":"e_1_2_9_4_3","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2018.00411"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41571-021-00585-y"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41576-019-0158-7"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13112744"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.18632\/aging.101997"},{"key":"e_1_2_9_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-019-0594-6"},{"key":"e_1_2_9_8_3","doi-asserted-by":"publisher","DOI":"10.1016\/j.omtn.2020.04.017"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.30200"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2019.05.009"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10142-018-0631-y"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2019.111753"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40164-022-00302-0"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40164-022-00298-7"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2020.03.011"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature15395"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1101\/gr.202895.115"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M901026200"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2022.04.021"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abn9232"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkx1030"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202300953"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature24678"},{"key":"e_1_2_9_23_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm.4416"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2017.11.031"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-021-03536-w"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-021-01124-5"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.7819"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41580-020-0243-y"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagrm.2022.194825"},{"key":"e_1_2_9_29_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkac213"},{"key":"e_1_2_9_29_3","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-022-00905-3"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-12651-2"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.51342"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2021.633750"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/s43018-021-00216-6"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI23409"},{"key":"e_1_2_9_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.beha.2007.03.007"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1158\/1541-7786.MCR-17-0026"},{"key":"e_1_2_9_35_2","doi-asserted-by":"publisher","DOI":"10.1101\/gr.152132.112"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-10-532200"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2020005734"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/1878-0261.13281"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1527-3466.2007.00006.x"},{"key":"e_1_2_9_39_2","doi-asserted-by":"publisher","DOI":"10.1097\/FTD.0000000000000237"},{"key":"e_1_2_9_39_3","doi-asserted-by":"publisher","DOI":"10.1042\/CS20060307"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2012.329"},{"key":"e_1_2_9_40_2","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.15751"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/ctm2.798"},{"key":"e_1_2_9_41_2","doi-asserted-by":"crossref","DOI":"10.1155\/2022\/5885342","volume":"2022","author":"Liu W.","year":"2022","journal-title":"Oxid. Med. Cell. Longev."},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.3791\/3912"}],"container-title":["Advanced Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/advs.202304895","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T23:46:05Z","timestamp":1759794365000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/advs.202304895"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10,11]]},"references-count":57,"journal-issue":{"issue":"34","published-print":{"date-parts":[[2023,12]]}},"alternative-id":["10.1002\/advs.202304895"],"URL":"https:\/\/doi.org\/10.1002\/advs.202304895","archive":["Portico"],"relation":{},"ISSN":["2198-3844","2198-3844"],"issn-type":[{"value":"2198-3844","type":"print"},{"value":"2198-3844","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,10,11]]},"assertion":[{"value":"2023-07-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-10-11","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"2304895"}}