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The immunosuppressive extracellular vesicles (EVs)\u2010based approach has been proven to be effective in treating autoimmune\/inflammatory disorders. Herein, the anti\u2010rejection advantage of exosomes (Rapa\u2010Exo) from rapamycin\u2010conditioned myeloid\u2010derived suppressor cells (MDSCs) over exosomes (Exo\u2010Nor) from the untreated MDSCs is shown. The exosomal small RNA sequencing and loss\u2010of\u2010function assays reveal that the anti\u2010rejection effect of Rapa\u2010Exo functionally relies on miR\u2010181d\u20105p. Through target prediction and double\u2010luciferase reporter assay, Kruppel\u2010like factor (KLF) 6 is identified as a direct target of miR\u2010181d\u20105p. Finally, KLF6 knockdown markedly resolves inflammation and prolongs the survival of corneal allografts. Taken together, these findings support that Rapa\u2010Exo executes an anti\u2010rejection effect, highlighting the immunosuppressive EVs\u2010based treatment as a promising approach in organ transplantation.<\/jats:p>","DOI":"10.1002\/advs.202304922","type":"journal-article","created":{"date-parts":[[2023,10,23]],"date-time":"2023-10-23T07:25:16Z","timestamp":1698045916000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Exosomal miR\u2010181d\u20105p Derived from Rapamycin\u2010Conditioned MDSC Alleviated Allograft Rejection by Targeting KLF6"],"prefix":"10.1002","volume":"10","author":[{"given":"Chao","family":"Wei","sequence":"first","affiliation":[{"name":"State Key Laboratory Cultivation Base Shandong Provincial Key Laboratory of Ophthalmology Eye Institute of Shandong First Medical University  Qingdao 266071 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaru","family":"Sun","sequence":"additional","affiliation":[{"name":"State Key Laboratory Cultivation Base Shandong Provincial Key Laboratory of Ophthalmology Eye Institute of Shandong First Medical University  Qingdao 266071 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fanxing","family":"Zeng","sequence":"additional","affiliation":[{"name":"State Key Laboratory Cultivation Base Shandong Provincial Key Laboratory of Ophthalmology Eye Institute of Shandong First Medical University  Qingdao 266071 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiunian","family":"Chen","sequence":"additional","affiliation":[{"name":"State Key Laboratory Cultivation Base Shandong Provincial Key Laboratory of Ophthalmology Eye Institute of Shandong First Medical University  Qingdao 266071 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Ma","sequence":"additional","affiliation":[{"name":"State Key Laboratory Cultivation Base Shandong Provincial Key Laboratory of Ophthalmology Eye Institute of Shandong First Medical University  Qingdao 266071 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoxue","family":"Liu","sequence":"additional","affiliation":[{"name":"State Key Laboratory Cultivation Base Shandong Provincial Key Laboratory of Ophthalmology Eye Institute of Shandong First Medical University  Qingdao 266071 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaolin","family":"Qi","sequence":"additional","affiliation":[{"name":"State Key Laboratory Cultivation Base Shandong Provincial Key Laboratory of Ophthalmology Eye Institute of Shandong First Medical University  Qingdao 266071 China"},{"name":"Eye Hospital of Shandong First Medical University (Shandong Eye Hospital)  Jinan 250117 China"},{"name":"School of Ophthalmology Shandong First Medical University &amp; 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