{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T20:23:20Z","timestamp":1791318200988,"version":"4.3.1"},"reference-count":52,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,12,11]],"date-time":"2023-12-11T00:00:00Z","timestamp":1702252800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82073266"],"award-info":[{"award-number":["82073266"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31970663"],"award-info":[{"award-number":["31970663"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013105","name":"Shanghai Rising-Star Program","doi-asserted-by":"publisher","award":["23QA1411700"],"award-info":[{"award-number":["23QA1411700"]}],"id":[{"id":"10.13039\/501100013105","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Destruction of cartilage due to the abnormal remodeling of subchondral bone (SB) leads to osteoarthritis (OA), and restoring chondro\u2010bone metabolic homeostasis is the key to the treatment of OA. However, traditional intra\u2010articular injections for the treatment of OA cannot directly break through the cartilage barrier to reach SB. In this study, the hydrothermal method is used to synthesize ultra\u2010small size (\u22485\u00a0nm) selenium\u2010doped carbon quantum dots (Se\u2010CQDs, SC), which conjugated with triphenylphosphine (TPP) to create TPP\u2010Se\u2010CQDs (SCT). Further, SCT is dynamically complexed with hyaluronic acid modified with aldehyde and methacrylic anhydride (AHAMA) to construct highly permeable micro\/nano hydrogel microspheres (SCT@AHAMA) for restoring chondro\u2010bone metabolic homeostasis. In vitro experiments confirmed that the selenium atoms scavenged reactive oxygen species (ROS) from the mitochondria of mononuclear macrophages, inhibited osteoclast differentiation and function, and suppressed early chondrocyte apoptosis to maintain a balance between cartilage matrix synthesis and catabolism. In vivo experiments further demonstrated that the delivery system inhibited osteoclastogenesis and H\u2010vessel invasion, thereby regulating the initiation and process of abnormal bone remodeling and inhibiting cartilage degeneration in SB. In conclusion, the micro\/nano hydrogel microspheres based on ultra\u2010small quantum dots facilitate the efficient penetration of articular SB and regulate chondro\u2010bone metabolism for OA treatment.<\/jats:p>","DOI":"10.1002\/advs.202305023","type":"journal-article","created":{"date-parts":[[2023,12,12]],"date-time":"2023-12-12T16:02:38Z","timestamp":1702396958000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":76,"title":["Regulating Chondro\u2010Bone Metabolism for Treatment of Osteoarthritis via High\u2010Permeability Micro\/Nano Hydrogel Microspheres"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9027-5096","authenticated-orcid":false,"given":"Guilai","family":"Zuo","sequence":"first","affiliation":[{"name":"School of Health Science and Engineering University of Shanghai for Science and Technology  Shanghai 200093 P. R. China"},{"name":"Department of Orthopaedic Oncology Changzheng Hospital Naval Military Medical University  Shanghai 200003 P. R. China"},{"name":"Department of Bone Tumor The Affiliated Hospital of Qingdao University  No. 59, Haier Road Qingdao Shandong 266000 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pengzhen","family":"Zhuang","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases Shanghai Institute of Traumatology and Orthopaedics Ruijin Hospital Shanghai Jiao Tong University School of Medicine  197 Ruijin 2nd Road Shanghai 200025 P. R. China"},{"name":"Pharmaceutical Sciences Laboratory Faculty of Science and Engineering \u00c5bo Akademi University  Turku 20520 Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinghai","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Oncology Changzheng Hospital Naval Military Medical University  Shanghai 200003 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Jia","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Oncology Changzheng Hospital Naval Military Medical University  Shanghai 200003 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengwei","family":"Cai","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases Shanghai Institute of Traumatology and Orthopaedics Ruijin Hospital Shanghai Jiao Tong University School of Medicine  197 Ruijin 2nd Road Shanghai 200025 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Qi","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases Shanghai Institute of Traumatology and Orthopaedics Ruijin Hospital Shanghai Jiao Tong University School of Medicine  197 Ruijin 2nd Road Shanghai 200025 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lianfu","family":"Deng","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases Shanghai Institute of Traumatology and Orthopaedics Ruijin Hospital Shanghai Jiao Tong University School of Medicine  197 Ruijin 2nd Road Shanghai 200025 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenhua","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Oncology Changzheng Hospital Naval Military Medical University  Shanghai 200003 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6938-9582","authenticated-orcid":false,"given":"Wenguo","family":"Cui","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases Shanghai Institute of Traumatology and Orthopaedics Ruijin Hospital Shanghai Jiao Tong University School of Medicine  197 Ruijin 2nd Road Shanghai 200025 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianru","family":"Xiao","sequence":"additional","affiliation":[{"name":"School of Health Science and Engineering University of Shanghai for Science and Technology  Shanghai 200093 P. R. China"},{"name":"Department of Orthopaedic Oncology Changzheng Hospital Naval Military Medical University  Shanghai 200003 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,12,11]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keac539"},{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41413-021-00147-z"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2008.01.014"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2012.130"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41584-018-0033-5"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/SMMD.20220014"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abo7868"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41413-022-00201-4"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2015-207923"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI121561"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2020-218089"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2023.1156913"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20143576"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2012.01.005"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2022.121732"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2021.130066"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12951-021-00945-x"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2021.01.003"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmt.2023.01.005"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.snb.2021.131348"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.engreg.2023.01.004"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201705989"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jddst.2023.104241"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202107678"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmt.2022.11.012"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmt.2022.11.002"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202106591"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1177\/20417314231164765"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202302007"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.matt.2021.09.022"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abl6449"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/SMMD.20220038"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2020.11.020"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.78639"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2020.110452"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.216267"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-09-3662"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1177\/20417314231172584"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.3390\/jdb3040177"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.34133\/research.0068"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1177\/1759720X13514669"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature13145"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202207089"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.135446"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcis.2020.02.011"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1002\/SMMD.20220027"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.engreg.2021.12.003"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmt.2022.10.001"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202001032"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2021.133018"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2020.05.004"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202201457"}],"container-title":["Advanced Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/advs.202305023","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T13:17:14Z","timestamp":1759756634000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/advs.202305023"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12,11]]},"references-count":52,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2024,2]]}},"alternative-id":["10.1002\/advs.202305023"],"URL":"https:\/\/doi.org\/10.1002\/advs.202305023","archive":["Portico"],"relation":{},"ISSN":["2198-3844","2198-3844"],"issn-type":[{"value":"2198-3844","type":"print"},{"value":"2198-3844","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,12,11]]},"assertion":[{"value":"2023-07-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-12-11","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"2305023"}}