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By producing large amounts of reactive oxygen species (ROS), PDT can effectively eliminate pathogenic bacteria, without causing drug resistance. However, excessive ROS may also impose an oxidative stress on surrounding tissues, resulting in local inflammation. To avoid this major drawback and limit pro\u2010inflammation during PDT, this work prepared a supramolecular photosensitizer (<jats:bold>TPP\u2010CN\/CP5<\/jats:bold>) based on host\u2010guest interactions between a cysteine\u2010responsive cyano\u2010tetraphenylporphyrin (<jats:bold>TPP\u2010CN<\/jats:bold>) and a water\u2010soluble carboxylatopillar[5]arene (<jats:bold>CP5<\/jats:bold>). <jats:bold>TPP\u2010CN\/CP5<\/jats:bold> not only possesses excellent photodynamic antibacterial properties, but also shows good anti\u2010inflammatory and cell protection capabilities. Under 660\u00a0nm light irradiation, <jats:bold>TPP\u2010CN\/CP5<\/jats:bold> could rapidly produce abundant ROS for sterilization. After the PDT process, the addition of cysteine (Cys) triggers the release of H<jats:sub>2<\/jats:sub>S from <jats:bold>TPP\u2010CN<\/jats:bold>. H<jats:sub>2<\/jats:sub>S then stops the induced inflammation by inhibiting the production of related inflammatory factors. Both in vitro and in vivo experiments show the excellent antibacterial effects and anti\u2010inflammatory abilities of <jats:bold>TPP\u2010CN\/CP5<\/jats:bold>. These results will certainly promote the clinical application of PDT in the treatment of bacterial infectious diseases.<\/jats:p>","DOI":"10.1002\/advs.202305183","type":"journal-article","created":{"date-parts":[[2023,12,14]],"date-time":"2023-12-14T09:01:38Z","timestamp":1702544498000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":46,"title":["A H<sub>2<\/sub>S\u2010Generated Supramolecular Photosensitizer for Enhanced Photodynamic Antibacterial Infection and Relieving Inflammation"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7391-4522","authenticated-orcid":false,"given":"Jia","family":"Tian","sequence":"first","affiliation":[{"name":"Shanghai Key Laboratory of Functional Materials Chemistry East China University of Science and Technology  Shanghai 200237 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