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Consequently, sophisticated transdermal transfersome nanogels (TA\/Fu\u2010TS) are prepared to control HS formation by synergistically inhibiting inflammation and suppressing fibrosis. TA\/Fu\u2010TSs have unique structures comprising hydrophobic triamcinolone acetonide (TA) in lipid multilayers and hydrophilic 5\u2010fluorouracil in aqueous cores, and perform satisfactorily with regard to transdermal co\u2010delivery to macrophages and HS fibroblasts in emerging HS tissues. According to the in vitro<jats:italic>\/<\/jats:italic>vivo results, TA\/Fu\u2010TSs not only promote macrophage phenotype\u2010switching to inhibit inflammation by interleukin\u2010related pathways, but also suppress fibrosis to remodel extracellular matrix by collagen\u2010related pathways. Therefore, TA\/Fu\u2010TSs overcome prolonged inflammation and excessive fibrosis in emerging HS tissues, and provide an effective therapeutic strategy for controlling HS formation via their synergy of macrophage phenotype\u2010switching and anti\u2010fibrosis effect.<\/jats:p>","DOI":"10.1002\/advs.202305468","type":"journal-article","created":{"date-parts":[[2023,12,8]],"date-time":"2023-12-08T12:04:20Z","timestamp":1702037060000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Transdermal Transfersome Nanogels Control Hypertrophic Scar Formation via Synergy of Macrophage Phenotype\u2010Switching and Anti\u2010Fibrosis Effect"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2086-9833","authenticated-orcid":false,"given":"Yunsheng","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Burn Shanghai Burn Institute Ruijin Hospital Shanghai Jiao Tong University School of Medicine  197 Ruijin 2nd Road Shanghai 200025 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kun","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Burn and Plastic Surgery Beijing Children's Hospital Capital Medical University National Center for Children's Health  Beijing 100045 China"},{"name":"Shunyi Maternal and Children's Hospital of Beijing Children's Hospital  Beijing 101300 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shan","family":"Zhong","sequence":"additional","affiliation":[{"name":"Department of Burn Shanghai Burn Institute Ruijin Hospital Shanghai Jiao Tong University School of Medicine  197 Ruijin 2nd Road Shanghai 200025 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaqiang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Burn Shanghai Burn Institute Ruijin Hospital Shanghai Jiao Tong University School of Medicine  197 Ruijin 2nd Road Shanghai 200025 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhixi","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery Shanghai Ninth People's Hospital School of Medicine Shanghai Jiao Tong University  639 Zhizaoju Rd Shanghai 200011 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiyang","family":"Sun","sequence":"additional","affiliation":[{"name":"Hongqiao International Institute of Medicine Tongren Hospital School of Medicine Shanghai Jiao Tong University  1111 XianXia Road Shanghai 200336 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Ear Reconstruction Plastic Surgery Hospital Chinese Academy of Medical Sciences and Peking Union Medical College  33 Badachu Road Beijing 100144 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Burn Shanghai Burn Institute Ruijin Hospital Shanghai Jiao Tong University School of Medicine  197 Ruijin 2nd Road Shanghai 200025 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery Shanghai Ninth People's Hospital School of Medicine Shanghai Jiao Tong University  639 Zhizaoju Rd Shanghai 200011 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,12,8]]},"reference":[{"key":"e_1_2_8_1_1","doi-asserted-by":"publisher","DOI":"10.1093\/burnst\/tkz003"},{"key":"e_1_2_8_1_2","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202100407"},{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0000000000008667"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2019.119267"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.1c11016"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/burnst\/tkac015"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.603187"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbc.2021.101530"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2018.12.027"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202206771"},{"key":"e_1_2_8_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/rb\/rbac065"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202111003"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.0c09842"},{"key":"e_1_2_8_8_2","first-page":"261","volume":"12","author":"Chen Y.","year":"2020","journal-title":"Am. 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