{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T18:06:06Z","timestamp":1793124366918,"version":"4.5.0"},"reference-count":92,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2024,1,15]],"date-time":"2024-01-15T00:00:00Z","timestamp":1705276800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82122019"],"award-info":[{"award-number":["82122019"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82371145"],"award-info":[{"award-number":["82371145"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82201275"],"award-info":[{"award-number":["82201275"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82371144"],"award-info":[{"award-number":["82371144"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81730028"],"award-info":[{"award-number":["81730028"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81970872"],"award-info":[{"award-number":["81970872"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007219","name":"Natural Science Foundation of Shanghai Municipality","doi-asserted-by":"publisher","award":["21ZR1437600"],"award-info":[{"award-number":["21ZR1437600"]}],"id":[{"id":"10.13039\/100007219","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>There are no Food and Drug Administration\u2010approved drugs for treating noise\u2010induced hearing loss (NIHL), reflecting the absence of clear specific therapeutic targets and effective delivery strategies. Noise trauma is demonstrated results in nicotinamide adenine dinucleotide (NAD+) downregulation and mitochondrial dysfunction in cochlear hair cells (HCs) and spiral ganglion neurons (SGNs) in mice, and NAD+ boosted by nicotinamide (NAM) supplementation maintains cochlear mitochondrial homeostasis and prevents neuroexcitatory toxic injury in vitro and ex vivo, also significantly ameliorated NIHL in vivo. To tackle the limited drug delivery efficiency due to sophisticated anatomical barriers and unique clearance pathway in ear, personalized NAM\u2010encapsulated porous gelatin methacryloyl (PGMA@NAM) are developed based on anatomy topography of murine temporal bone by micro\u2010computed tomography and reconstruction of round window (RW) niche, realizing hydrogel in situ implantation completely, NAM sustained\u2010release and long\u2010term auditory preservation in mice. This study strongly supports personalized PGMA@NAM as NIHL protection drug with effective inner ear delivery, providing new inspiration for drug\u2010based treatment of NIHL.<\/jats:p>","DOI":"10.1002\/advs.202305682","type":"journal-article","created":{"date-parts":[[2024,1,16]],"date-time":"2024-01-16T00:17:06Z","timestamp":1705364226000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Personalized Porous Gelatin Methacryloyl Sustained\u2010Release Nicotinamide Protects Against Noise\u2010Induced Hearing Loss"],"prefix":"10.1002","volume":"11","author":[{"given":"Baoyi","family":"Feng","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine  No.639, Zhizaoju Road Shanghai 200011 P. R. China"},{"name":"Ear Institute Shanghai Jiao Tong University School of Medicine  No.115, Jinzun Road Shanghai 200125 P. R. China"},{"name":"Shanghai Key Laboratory of Translation Medicine on Ear and Nose Disease  No.115, Jinzun Road Shanghai 200125 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingting","family":"Dong","sequence":"additional","affiliation":[{"name":"Ear Institute Shanghai Jiao Tong University School of Medicine  No.115, Jinzun Road Shanghai 200125 P. R. China"},{"name":"Shanghai Key Laboratory of Translation Medicine on Ear and Nose Disease  No.115, Jinzun Road Shanghai 200125 P. R. China"},{"name":"Biobank of Ninth People's Hospital Shanghai Jiao Tong University School of Medicine  No.115, Jinzun Road Shanghai 200125 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyu","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Prosthodontics Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine Shanghai 200011 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaofei","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine  No.639, Zhizaoju Road Shanghai 200011 P. R. China"},{"name":"Ear Institute Shanghai Jiao Tong University School of Medicine  No.115, Jinzun Road Shanghai 200125 P. R. China"},{"name":"Shanghai Key Laboratory of Translation Medicine on Ear and Nose Disease  No.115, Jinzun Road Shanghai 200125 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenxi","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine  No.639, Zhizaoju Road Shanghai 200011 P. R. China"},{"name":"Ear Institute Shanghai Jiao Tong University School of Medicine  No.115, Jinzun Road Shanghai 200125 P. R. China"},{"name":"Shanghai Key Laboratory of Translation Medicine on Ear and Nose Disease  No.115, Jinzun Road Shanghai 200125 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenzhe","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine  No.639, Zhizaoju Road Shanghai 200011 P. R. China"},{"name":"Ear Institute Shanghai Jiao Tong University School of Medicine  No.115, Jinzun Road Shanghai 200125 P. R. China"},{"name":"Shanghai Key Laboratory of Translation Medicine on Ear and Nose Disease  No.115, Jinzun Road Shanghai 200125 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiqing","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine  No.639, Zhizaoju Road Shanghai 200011 P. R. China"},{"name":"Ear Institute Shanghai Jiao Tong University School of Medicine  No.115, Jinzun Road Shanghai 200125 P. R. China"},{"name":"Shanghai Key Laboratory of Translation Medicine on Ear and Nose Disease  No.115, Jinzun Road Shanghai 200125 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjie","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Prosthodontics Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine Shanghai 200011 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueling","family":"Wang","sequence":"additional","affiliation":[{"name":"Ear Institute Shanghai Jiao Tong University School of Medicine  No.115, Jinzun Road Shanghai 200125 P. R. China"},{"name":"Shanghai Key Laboratory of Translation Medicine on Ear and Nose Disease  No.115, Jinzun Road Shanghai 200125 P. R. China"},{"name":"Biobank of Ninth People's Hospital Shanghai Jiao Tong University School of Medicine  No.115, Jinzun Road Shanghai 200125 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Tao","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine  No.639, Zhizaoju Road Shanghai 200011 P. R. China"},{"name":"Ear Institute Shanghai Jiao Tong University School of Medicine  No.115, Jinzun Road Shanghai 200125 P. R. China"},{"name":"Shanghai Key Laboratory of Translation Medicine on Ear and Nose Disease  No.115, Jinzun Road Shanghai 200125 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5317-902X","authenticated-orcid":false,"given":"Hao","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine  No.639, Zhizaoju Road Shanghai 200011 P. R. China"},{"name":"Ear Institute Shanghai Jiao Tong University School of Medicine  No.115, Jinzun Road Shanghai 200125 P. R. China"},{"name":"Shanghai Key Laboratory of Translation Medicine on Ear and Nose Disease  No.115, Jinzun Road Shanghai 200125 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,1,15]]},"reference":[{"key":"e_1_2_9_1_1","unstructured":"O.World Health World report on hearing World Health Organization Geneva2021."},{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2019.02.022"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1903315116"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajim.20223"},{"key":"e_1_2_9_4_2","doi-asserted-by":"publisher","DOI":"10.1517\/14728214.2011.552427"},{"key":"e_1_2_9_5_1","first-page":"100","volume":"14","author":"Kumar U. A.","year":"2012","journal-title":"Noise Health"},{"key":"e_1_2_9_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.heares.2016.10.018"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/00016480601110188"},{"key":"e_1_2_9_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-5955(03)00178-3"},{"key":"e_1_2_9_6_3","doi-asserted-by":"publisher","DOI":"10.1016\/j.heares.2011.08.003"},{"key":"e_1_2_9_6_4","doi-asserted-by":"publisher","DOI":"10.3390\/antiox9121177"},{"key":"e_1_2_9_6_5","doi-asserted-by":"publisher","DOI":"10.1177\/0194599814553930"},{"key":"e_1_2_9_6_6","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-018-5161-7"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heares.2006.05.006"},{"key":"e_1_2_9_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jphs.2017.07.003"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1080\/17460441.2020.1806232"},{"key":"e_1_2_9_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/lary.27713"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2014.6004"},{"key":"e_1_2_9_9_2","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2021.1905466"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abd0561"},{"key":"e_1_2_9_10_2","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.648461"},{"key":"e_1_2_9_10_3","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2017.03.058"},{"key":"e_1_2_9_10_4","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2007.02.007"},{"key":"e_1_2_9_10_5","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-5955(01)00361-6"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heares.2017.01.003"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2012.02.035"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox8040109"},{"key":"e_1_2_9_13_2","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/617207"},{"key":"e_1_2_9_13_3","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.744838"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.aud.0000191942.36672.f3"},{"key":"e_1_2_9_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.heares.2013.01.006"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.6381-11.2012"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2019.101406"},{"key":"e_1_2_9_16_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0782-16.2016"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1080\/13543784.2017.1269171"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2014.11.003"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2282-12.2013"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20172246"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41580-020-00313-x"},{"key":"e_1_2_9_21_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.aac4854"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcb.2014.04.002"},{"key":"e_1_2_9_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2019.09.001"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2018.02.011"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/acel.13016"},{"key":"e_1_2_9_24_2","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2014.255"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2011.08.014"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2013.11.037"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxlet.2021.05.013"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41514-019-0040-z"},{"key":"e_1_2_9_28_2","doi-asserted-by":"publisher","DOI":"10.1111\/acel.13909"},{"key":"e_1_2_9_29_1","unstructured":"M. A.\u2010O.Damgaard J. A.\u2010O.Treebak (2375\u20102548 (Electronic))."},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2018.02.001"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aal0092"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2015.08.015"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.5152\/tao.2018.3467"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2021.809443"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202106591"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S245188"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.2c11647"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-981-13-6123-4_3"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2018.04.047"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1434-10.2011"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1159\/000241892"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016489.2014.951455"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1007\/s101620020028"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2845-09.2009"},{"key":"e_1_2_9_44_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2019.11.051"},{"key":"e_1_2_9_44_3","doi-asserted-by":"publisher","DOI":"10.1007\/s10162-011-0277-0"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2228-18.2019"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016489.2012.659755"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/8823785"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-020-00311-7"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.adi4862"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2016.09.013"},{"key":"e_1_2_9_50_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10522-019-09805-6"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.2337\/db14-0667"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2018.03.018"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1159\/000013846"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2021.101988"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2019.02.012"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2019.00300"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1089\/hum.2016.053"},{"key":"e_1_2_9_57_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature25164"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2015.08.045"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2020.03.030"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aaf4363"},{"key":"e_1_2_9_61_1","doi-asserted-by":"publisher","DOI":"10.1088\/1748-605X\/ac1e9d"},{"key":"e_1_2_9_62_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-42186-x"},{"key":"e_1_2_9_63_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.8b06205"},{"key":"e_1_2_9_64_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202102433"},{"key":"e_1_2_9_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.msec.2021.111868"},{"key":"e_1_2_9_66_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1489-13.2013"}],"container-title":["Advanced Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/advs.202305682","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T15:16:39Z","timestamp":1759763799000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/advs.202305682"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1,15]]},"references-count":92,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2024,3]]}},"alternative-id":["10.1002\/advs.202305682"],"URL":"https:\/\/doi.org\/10.1002\/advs.202305682","archive":["Portico"],"relation":{},"ISSN":["2198-3844","2198-3844"],"issn-type":[{"value":"2198-3844","type":"print"},{"value":"2198-3844","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1,15]]},"assertion":[{"value":"2023-08-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-01-15","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"2305682"}}