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This study conduct a Cox regression analysis to screen mRNA\u2010binding proteins and reveals an association between Ras GTPase\u2010activating protein\u2010binding protein 1 (G3BP1) and diminished effectiveness of ICI therapy in patients with advanced BLCA. Subsequent investigation demonstrates that G3BP1 enhances immune evasion in BLCA cells by downregulating major histocompatibility complex class I (MHC\u2010I) through phosphoinositide 3\u2010kinase (PI3K)\/Akt signaling activation. Mechanistically, G3BP1 interacts with splicing factor synergistic lethal with U5 snRNA 7 (SLU7) to form a complex with poly(A)\u2010binding protein cytoplasmic 1 and eukaryotic translation initiation factor 4 gamma 1. This complex stabilizes the closed\u2010loop structure of the mRNAs of class IA PI3Ks and consequently facilitates their translation and stabilization, thereby activating PI3K\/Akt signaling to downregulate MHC\u2010I. Consistently, targeting G3BP1 with epigallocatechin gallate (EGCG) impedes immune evasion and sensitizes BLCA cells to anti\u2010programmed cell death (PD)\u20101 antibodies in mice. Thus, G3BP1 and SLU7 collaboratively contribute to immune evasion in BLCA, indicating that EGCG is a precision therapeutic agent to enhance the effectiveness of anti\u2010PD\u20101 therapy.<\/jats:p>","DOI":"10.1002\/advs.202305922","type":"journal-article","created":{"date-parts":[[2023,12,12]],"date-time":"2023-12-12T16:57:00Z","timestamp":1702400220000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["G3BP1 and SLU7 Jointly Promote Immune Evasion by Downregulating MHC\u2010I via PI3K\/Akt Activation in Bladder Cancer"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8005-6519","authenticated-orcid":false,"given":"Xianchong","family":"Zheng","sequence":"first","affiliation":[{"name":"Department of Urology Sun Yat\u2010sen University Cancer Center  Guangzhou 510060 P. R. 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