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Hepatolithiasis is once considered the primary cause of ICC, although recent insights indicate that bacteria in the occurrence of hepatolithiasis can promote the progression of ICC. By constructing in vitro and in vivo ICC models and patient\u2010derived organoids (PDOs), it is shown that <jats:italic>Escherichia coli<\/jats:italic> induces the production of a novel RNA, circGLIS3 (cGLIS3), which promotes tumor growth. cGLIS3 binds to hnRNPA1 and G3BP1, resulting in the assembly of stress granules (SGs) and suppression of hnRNPA1 and G3BP1 ubiquitination. Consequently, the IKK\u03b1 mRNA is blocked in SGs, decreasing the production of IKK\u03b1 and activating the NF\u2010\u03baB pathway, which finally results in chemoresistance and produces metastatic phenotypes of ICC. This study shows that a combination of Icaritin (ICA) and gemcitabine plus cisplatin (GP) chemotherapy can be a promising treatment strategy for ICC.<\/jats:p>","DOI":"10.1002\/advs.202306174","type":"journal-article","created":{"date-parts":[[2024,2,17]],"date-time":"2024-02-17T21:59:06Z","timestamp":1708207146000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["<i>Escherichia coli<\/i>\u2010Induced cGLIS3\u2010Mediated Stress Granules Activate the NF\u2010\u03baB Pathway to Promote Intrahepatic Cholangiocarcinoma Progression"],"prefix":"10.1002","volume":"11","author":[{"given":"Feng\u2010Ping","family":"Kang","sequence":"first","affiliation":[{"name":"Shengli Clinical Medical College of Fujian Medical University  Fuzhou 350001 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