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Herein, the role and the mechanism of impaired GI motility in colitis pathogenesis are investigated. Increased colonic mucosal inflammation is found in patients with chronic constipation (CC). Mice with GI dysmotility induced by genetic mutation or chemical insult exhibit increased susceptibility to colitis, dependent on the gut microbiota. GI dysmotility markedly decreases the abundance of\n                    <jats:italic>Lactobacillus animlalis<\/jats:italic>\n                    and increases the abundance of\n                    <jats:italic>Akkermansia muciniphila<\/jats:italic>\n                    . The reduction in\n                    <jats:italic>L. animlalis<\/jats:italic>\n                    , leads to the accumulation of linoleic acid due to compromised conversion to conjugated linoleic acid. The accumulation of linoleic acid inhibits Treg cell differentiation and increases colitis susceptibility via inducing macrophage infiltration and proinflammatory cytokine expression in macrophage.\n                    <jats:italic>Lactobacillus<\/jats:italic>\n                    and\n                    <jats:italic>A. muciniphila<\/jats:italic>\n                    abnormalities are also observed in CC and IBD patients, and mice receiving fecal microbiota from CC patients displayed an increased susceptibility to colitis. These findings suggest that GI dysmotility predisposes host to colitis development by modulating the composition of microbiota and facilitating linoleic acid accumulation. Targeted modulation of microbiota and linoleic acid metabolism may be promising to protect patients with motility disorder from intestinal inflammation.\n                  <\/jats:p>","DOI":"10.1002\/advs.202306297","type":"journal-article","created":{"date-parts":[[2024,3,13]],"date-time":"2024-03-13T08:34:57Z","timestamp":1710318897000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["Gastrointestinal Dysmotility Predisposes to Colitis through Regulation of Gut Microbial Composition and Linoleic Acid Metabolism"],"prefix":"10.1002","volume":"11","author":[{"given":"Youhua","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Pathology Shanghai Tenth People's Hospital, Tongji University School of Medicine  Shanghai 200072 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feifei","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Pathology 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