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Previous studies showed that the tumor microenvironment of BM in these patients is immunosuppressed, as indicated by reduced T\u2010cell abundance and activity, although the mechanism of this immunosuppression requires further study. This study shows that reactive astrocytes play a critical role in promoting the immune escape of BM from\n                    <jats:italic>EGFR<\/jats:italic>\n                    \u2010mutated NSCLC by increasing the apoptosis of CD8\n                    <jats:sup>+<\/jats:sup>\n                    T lymphocytes. The increased secretion of interleukin 11(IL11) by astrocytes promotes the expression of PDL1 in BM, and this is responsible for the increased apoptosis of T lymphocytes. IL11 functions as a ligand of EGFR, and this binding activates EGFR and downstream signaling to increase the expression of PDL1, culminating in the immune escape of tumor cells. IL11 also promotes immune escape by binding to its intrinsic receptor (IL11R\u03b1\/glycoprotein 130 [gp130]). Additional in vivo studies show that the targeted inhibition of gp130 and EGFR suppresses the growth of BM and prolongs the survival time of mice. These results suggest a novel therapeutic strategy for treatment of NSCLC patients with\n                    <jats:italic>EGFR<\/jats:italic>\n                    mutations.\n                  <\/jats:p>","DOI":"10.1002\/advs.202306348","type":"journal-article","created":{"date-parts":[[2024,5,2]],"date-time":"2024-05-02T14:18:42Z","timestamp":1714659522000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Brain Metastasis from\n                    <i>EGFR<\/i>\n                    \u2010Mutated Non\u2010Small Cell Lung Cancer: Secretion of IL11 from Astrocytes Up\u2010Regulates PDL1 and Promotes Immune Escape"],"prefix":"10.1002","volume":"11","author":[{"given":"Mengyi","family":"Tang","sequence":"first","affiliation":[{"name":"the Second Affiliated Hospital of Dalian Medical University  467 Zhongshan Road Dalian 116027 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