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However, the precise mechanism remains unclear. Herein, the study identifies a crucial protein, axonemal dynein light intermediate polypeptide 1 (DNALI1), and elucidated its potential pathogenic role in post\u2010TBI neurodegeneration. The\n                    <jats:italic>DNALI1<\/jats:italic>\n                    gene is systematically screened through analyses of Aging, Dementia, and TBI studies, confirming its elevated expression both in vitro and in vivo. Moreover, it is observed that altered DNALI1 expression under normal conditions has no discernible effect. However, upon overexpression, DNALI1 inhibits autophagosome\u2010lysosome fusion, reduces autophagic flux, and exacerbates cell death under pathological conditions. DNALI1 silencing significantly enhances autophagic flux and alleviates neurodegeneration in a CTE model. These findings highlight DNALI1 as a potential key target for preventing TBI\u2010related neurodegeneration.\n                  <\/jats:p>","DOI":"10.1002\/advs.202306399","type":"journal-article","created":{"date-parts":[[2024,2,13]],"date-time":"2024-02-13T04:20:55Z","timestamp":1707798055000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["DNALI1 Promotes Neurodegeneration after Traumatic Brain Injury via Inhibition of Autophagosome\u2010Lysosome Fusion"],"prefix":"10.1002","volume":"11","author":[{"given":"Xulong","family":"Ding","sequence":"first","affiliation":[{"name":"Department of Neurology and State Key Laboratory of Biotherapy National Clinical Research Center for Geriatrics West China Hospital Sichuan University  Chengdu 610041 China"},{"name":"Center of Translational Medicine and Clinical Laboratory The Fourth Affiliated Hospital of Soochow University Medical Center of Soochow University Suzhou Dushu Lake Hospital  Suzhou Jiangsu 215123 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuqiang","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Forensic Genetics West China School of Basic Science and Forensic Medicine Sichuan University  Chengdu 610041 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurology and State Key Laboratory of Biotherapy National Clinical Research Center for Geriatrics West China Hospital Sichuan University  Chengdu 610041 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Du","sequence":"additional","affiliation":[{"name":"Department of Neurology and State Key Laboratory of Biotherapy National Clinical Research Center for Geriatrics West China Hospital Sichuan University  Chengdu 610041 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kefeng","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Neurology and State Key Laboratory of Biotherapy National Clinical Research Center for Geriatrics West China Hospital Sichuan University  Chengdu 610041 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiqian","family":"Qi","sequence":"additional","affiliation":[{"name":"Department of Neurology and State Key Laboratory of Biotherapy National Clinical Research Center for Geriatrics West China Hospital Sichuan University  Chengdu 610041 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Neurology and State Key Laboratory of Biotherapy National Clinical Research Center for Geriatrics West China Hospital Sichuan University  Chengdu 610041 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing\u2010zhang","family":"Tuo","sequence":"additional","affiliation":[{"name":"Department of Neurology and State Key Laboratory of Biotherapy National Clinical Research Center for Geriatrics West China Hospital Sichuan University  Chengdu 610041 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weibo","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Forensic Genetics West China School of Basic Science and Forensic Medicine Sichuan University  Chengdu 610041 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5652-1962","authenticated-orcid":false,"given":"Peng","family":"Lei","sequence":"additional","affiliation":[{"name":"Department of Neurology and State Key Laboratory of Biotherapy National Clinical Research Center for Geriatrics West China Hospital Sichuan University  Chengdu 610041 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,2,13]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2016.84"},{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.23736\/S0390-5616.18.04532-0"},{"key":"e_1_2_9_2_2","unstructured":"b)N. 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