{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T03:16:10Z","timestamp":1785294970589,"version":"3.55.0"},"reference-count":54,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2023,12,11]],"date-time":"2023-12-11T00:00:00Z","timestamp":1702252800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Manganese phosphosulphide (MnPS<jats:sub>3<\/jats:sub>), a newly emerged and promising member of the 2D metal phosphorus trichalcogenides (MPX<jats:sub>3<\/jats:sub>) family, has aroused abundant interest due to its unique physicochemical properties and applications in energy storage and conversion. However, its potential in the field of biomedicine, particularly as a nanotherapeutic platform for cancer therapy, has remained largely unexplored. Herein, a 2D \u201call\u2010in\u2010one\u201d theranostic nanoplatform based on MnPS<jats:sub>3<\/jats:sub> is designed and applied for imaging\u2010guided synergistic photothermal\u2010chemodynamic therapy. (Iron) Fe (II) ions are immobilized on the surface of MnPS<jats:sub>3<\/jats:sub> nanosheets to facilitate effective chemodynamic therapy (CDT). Upon surface modification with polydopamine (PDA) and polyethylene glycol (PEG), the obtained Fe\u2010MnPS<jats:sub>3<\/jats:sub>\/PDA\u2010PEG nanosheets exhibit exceptional photothermal conversion efficiency (<jats:italic>\u03b7<\/jats:italic>\u00a0=\u00a040.7%) and proficient pH\/NIR\u2010responsive Fenton catalytic activity, enabling efficient photothermal therapy (PTT) and CDT. Importantly, such nanoplatform can also serve as an efficient theranostic agent for multimodal imaging, facilitating real\u2010time monitoring and guidance of the therapeutic process. After fulfilling the therapeutic functions, the Fe\u2010MnPS<jats:sub>3<\/jats:sub>\/PDA\u2010PEG nanosheets can be efficiently excreted from the body, alleviating the concerns of long\u2010term retention and potential toxicity. This work presents an effective, precise, and safe 2D \u201call\u2010in\u2010one\u201d theranostic nanoplatform based on MnPS<jats:sub>3<\/jats:sub> for high\u2010efficiency tumor\u2010specific theranostics.<\/jats:p>","DOI":"10.1002\/advs.202306494","type":"journal-article","created":{"date-parts":[[2023,12,12]],"date-time":"2023-12-12T15:57:52Z","timestamp":1702396672000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Polydopamine\u2010Modified 2D Iron (II) Immobilized MnPS<sub>3<\/sub> Nanosheets for Multimodal Imaging\u2010Guided Cancer Synergistic Photothermal\u2010Chemodynamic Therapy"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-0617-2582","authenticated-orcid":false,"given":"Hanhan","family":"Xie","sequence":"first","affiliation":[{"name":"Shenzhen Key Laboratory of Biomimetic Robotics and Intelligent Systems Department of Mechanical and Energy Engineering Southern University of Science and Technology  Shenzhen 518055 China"},{"name":"Guangdong Provincial Key Laboratory of Human\u2010Augmentation and Rehabilitation Robotics in Universities Southern University of Science and Technology  Shenzhen 518055 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Yang","sequence":"additional","affiliation":[{"name":"Shenzhen Key Laboratory of Biomimetic Robotics and Intelligent Systems Department of Mechanical and Energy Engineering Southern University of Science and Technology  Shenzhen 518055 China"},{"name":"Guangdong Provincial Key Laboratory of Human\u2010Augmentation and Rehabilitation Robotics in Universities Southern University of Science and Technology  Shenzhen 518055 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoli","family":"He","sequence":"additional","affiliation":[{"name":"Shenzhen Key Laboratory of Biomimetic Robotics and Intelligent Systems Department of Mechanical and Energy Engineering Southern University of Science and Technology  Shenzhen 518055 China"},{"name":"Guangdong Provincial Key Laboratory of Human\u2010Augmentation and Rehabilitation Robotics in Universities Southern University of Science and Technology  Shenzhen 518055 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen","family":"Zhan","sequence":"additional","affiliation":[{"name":"Shenzhen Key Laboratory of Biomimetic Robotics and Intelligent Systems Department of Mechanical and Energy Engineering Southern University of Science and Technology  Shenzhen 518055 China"},{"name":"Guangdong Provincial Key Laboratory of Human\u2010Augmentation and Rehabilitation Robotics in Universities Southern University of Science and Technology  Shenzhen 518055 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huaide","family":"Jiang","sequence":"additional","affiliation":[{"name":"Shenzhen Key Laboratory of Biomimetic Robotics and Intelligent Systems Department of 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