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In this study, injectable \u201choming\u2010like\u201d bioactive decellularized extracellular matrix short\u2010fibers (DEFs) of porcine skin origin are innovatively designed for endometrial and fertility restoration. The DEFs can effectively bind to endometrial cells through noncovalent dipole interactions and release bioactive growth factors in situ. In vitro, the DEFs effectively attracted endometrial cells through the \u201choming\u2010like\u201d effect, enabling cell adhesion, spreading, and proliferation on their surface. Furthermore, the DEFs effectively facilitated the proliferation and angiogenesis of human primary endometrial stromal cells (HESCs) and human umbilical vein endothelial cells (HUVECs), and inhibited fibrosis of pretreated HESCs. In vivo, the DEFs significantly accelerated endometrial restoration, angiogenesis, and receptivity. Notably, the deposition of endometrial collagen decreased from 41.19 \u00b1 2.16% to 14.15 \u00b1 1.70% with DEFs treatment. Most importantly, in endometrium\u2010injured rats, the use of DEFs increased the live birth rate from 30% to an impressive 90%, and the number and development of live births close to normal rats. The injectable \u201choming\u2010like\u201d bioactive DEFs system can achieve efficient live births and intrauterine injection of DEFs provides a new promising clinical strategy for endometrial factor infertility.<\/jats:p>","DOI":"10.1002\/advs.202306507","type":"journal-article","created":{"date-parts":[[2024,3,20]],"date-time":"2024-03-20T01:39:24Z","timestamp":1710898764000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Injectable \u201cHoming\u2010Like\u201d Bioactive Short\u2010Fibers for Endometrial Repair and Efficient Live Births"],"prefix":"10.1002","volume":"11","author":[{"given":"Yumeng","family":"Cao","sequence":"first","affiliation":[{"name":"Department of Reproductive Medicine, Ren Ji Hospital Shanghai Jiao Tong University School of Medicine  Shanghai 200135 P. R. China"},{"name":"Shanghai Key Laboratory for Assisted Reproduction and Reproductive Genetics  Shanghai 200135 P. R. 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