{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T12:04:51Z","timestamp":1791374691419,"version":"4.3.1"},"reference-count":55,"publisher":"Wiley","issue":"23","license":[{"start":{"date-parts":[[2024,3,28]],"date-time":"2024-03-28T00:00:00Z","timestamp":1711584000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Cutaneous sympathetic nerve is a crucial part of neuropsychiatric factors contributing to skin immune response, but its role in the psoriasis pathogenesis remains unclear. It is found that cutaneous calcium\/calmodulin\u2010dependent protein kinase II\u2010\u03b3 (CAMK2\u03b3), expressed mainly in sympathetic nerves, is activated by stress and imiquimod in mouse skin.\n                    <jats:italic>Camk2g<\/jats:italic>\n                    \u2010deficient mice exhibits attenuated imiquimod\u2010induced psoriasis\u2010like manifestations and skin inflammation. CaMK2\u03b3 regulates dermal \u03b3\u03b4T\u2010cell interleukin\u201017 production in imiquimod\u2010treated mice, dependent on norepinephrine production following cutaneous sympathetic nerve activation. Adrenoceptor \u03b21, the primary skin norepinephrine receptor, colocalises with \u03b3\u03b4T cells. CaMK2\u03b3 aggravates psoriasiform inflammation via sympathetic nerve\u2013norepinephrine\u2013\u03b3\u03b4T cell\u2013adrenoceptor \u03b21\u2013nuclear factor\u2010\u03baB and \u2013p38 axis activation. Application of alcaftadine, a small\u2010molecule CaMK2\u03b3 inhibitor, relieves imiquimod\u2010induced psoriasis\u2010like manifestations in mice. This study reveals the mechanisms of sympathetic\u2010nervous\u2010system regulation of \u03b3\u03b4T\u2010cell interleukin\u201017 secretion, and provides insight into neuropsychiatric factors dictating psoriasis pathogenesis and new potential targets for clinical psoriasis treatment.\n                  <\/jats:p>","DOI":"10.1002\/advs.202306772","type":"journal-article","created":{"date-parts":[[2024,3,28]],"date-time":"2024-03-28T03:40:38Z","timestamp":1711597238000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Cutaneous Calcium\/Calmodulin\u2010Dependent Protein Kinase II\u2010\u03b3\u2013Positive Sympathetic Nerves Secreting Norepinephrine Dictate Psoriasis"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2138-5953","authenticated-orcid":false,"given":"Yafen","family":"Yu","sequence":"first","affiliation":[{"name":"Department of Dermatology the First Affiliated Hospital 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