{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T20:00:41Z","timestamp":1790971241780,"version":"4.1.0"},"reference-count":42,"publisher":"Wiley","issue":"20","license":[{"start":{"date-parts":[[2024,3,9]],"date-time":"2024-03-09T00:00:00Z","timestamp":1709942400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,3,9]],"date-time":"2024-03-09T00:00:00Z","timestamp":1709942400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81970909"],"award-info":[{"award-number":["81970909"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82271009"],"award-info":[{"award-number":["82271009"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["62076011"],"award-info":[{"award-number":["62076011"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["52373123"],"award-info":[{"award-number":["52373123"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["51973226"],"award-info":[{"award-number":["51973226"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["52373162"],"award-info":[{"award-number":["52373162"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004826","name":"Natural Science Foundation of Beijing Municipality","doi-asserted-by":"publisher","award":["L222116"],"award-info":[{"award-number":["L222116"]}],"id":[{"id":"10.13039\/501100004826","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004739","name":"Youth Innovation Promotion Association of the Chinese Academy of Sciences","doi-asserted-by":"publisher","award":["2019031"],"award-info":[{"award-number":["2019031"]}],"id":[{"id":"10.13039\/501100004739","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFA1206100"],"award-info":[{"award-number":["2022YFA1206100"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Inflammation\u2010responsive hydrogels loaded with therapeutic factors are effective biomaterials for bone tissue engineering and regenerative medicine. In this study, a matrix metalloproteinase (MMP)\u2010responsive injectable hydrogel is constructed by integrating an MMP\u2010cleavable peptide (pp) into a covalent tetra\u2010armed poly\u2010(ethylene glycol) (PEG) network for precise drug release upon inflammation stimulation. To establish a pro\u2010regenerative environment, phosphatidylserine (PS) is encapsulated into a scaffold to form the PEG\u2010pp\u2010PS network, which could be triggered by MMP to release a large amount of PS during the early stage of inflammation and retain drug release persistently until the later stage of bone repair. The hydrogel is found to be mechanically and biologically adaptable to the complex bone defect area. In vivo and in vitro studies further demonstrated the ability of PEG\u2010pp\u2010PS to transform macrophages into the anti\u2010inflammatory M2 phenotype and promote osteogenic differentiation, thus, resulting in new bone regeneration. Therefore, this study provides a facile, safe, and promising cell\u2010free strategy on simultaneous immunoregulation and osteoinduction in bone engineering.<\/jats:p>","DOI":"10.1002\/advs.202306924","type":"journal-article","created":{"date-parts":[[2024,3,9]],"date-time":"2024-03-09T15:03:53Z","timestamp":1709996633000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":59,"title":["Matrix Metalloproteinase\u2010Responsive Hydrogel with On\u2010Demand Release of Phosphatidylserine Promotes Bone Regeneration Through Immunomodulation"],"prefix":"10.1002","volume":"11","author":[{"given":"Mingjin","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Orthodontics Peking University School and Hospital of Stomatology  Beijing 100081 China"},{"name":"National Center of Stomatology &amp; National Clinical Research Center for Oral Diseases &amp; National Engineering Laboratory for Digital and Material Technology of Stomatology &amp; Beijing Key Laboratory for Digital Stomatology &amp; Research Center of Engineering and Technology for Computerized Dentistry Ministry of Health &amp; NMPA Key Laboratory for Dental Materials  Beijing 100081 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingting","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Orthodontics Peking University School and Hospital of Stomatology  Beijing 100081 China"},{"name":"National Center of Stomatology &amp; National Clinical Research Center for Oral Diseases &amp; National Engineering Laboratory for Digital and Material Technology of Stomatology &amp; Beijing Key Laboratory for Digital Stomatology &amp; Research Center of Engineering and Technology for Computerized Dentistry Ministry of Health &amp; NMPA Key Laboratory for Dental Materials  Beijing 100081 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Orthodontics Peking University School and Hospital of Stomatology  Beijing 100081 China"},{"name":"National Center of Stomatology &amp; National Clinical Research Center for Oral Diseases &amp; National Engineering Laboratory for Digital and Material Technology of Stomatology &amp; Beijing Key Laboratory for Digital Stomatology &amp; Research Center of Engineering and Technology for Computerized Dentistry Ministry of Health &amp; NMPA Key Laboratory for Dental Materials  Beijing 100081 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huichun","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Orthodontics Peking University School and Hospital of Stomatology  Beijing 100081 China"},{"name":"National Center of Stomatology &amp; National Clinical Research Center for Oral Diseases &amp; National Engineering Laboratory for Digital and Material Technology of Stomatology &amp; Beijing Key Laboratory for Digital Stomatology &amp; Research Center of Engineering and Technology for Computerized Dentistry Ministry of Health &amp; NMPA Key Laboratory for Dental Materials  Beijing 100081 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Lyu","sequence":"additional","affiliation":[{"name":"Department of Orthodontics Peking University School and Hospital of Stomatology  Beijing 100081 China"},{"name":"National Center of Stomatology &amp; National Clinical Research Center for Oral Diseases &amp; National Engineering Laboratory for Digital and Material Technology of Stomatology &amp; Beijing Key Laboratory for Digital Stomatology &amp; Research Center of Engineering and Technology for Computerized Dentistry Ministry of Health &amp; NMPA Key Laboratory for Dental Materials  Beijing 100081 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Orthodontics Peking University School and Hospital of Stomatology  Beijing 100081 China"},{"name":"National Center of Stomatology &amp; National Clinical Research Center for Oral Diseases &amp; National Engineering Laboratory for Digital and Material Technology of Stomatology &amp; Beijing Key Laboratory for Digital Stomatology &amp; Research Center of Engineering and Technology for Computerized Dentistry Ministry of Health &amp; NMPA Key Laboratory for Dental Materials  Beijing 100081 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gengchen","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Orthodontics Peking University School and Hospital of Stomatology  Beijing 100081 China"},{"name":"National Center of Stomatology &amp; National Clinical Research Center for Oral Diseases &amp; National Engineering Laboratory for Digital and Material Technology of Stomatology &amp; Beijing Key Laboratory for Digital Stomatology &amp; Research Center of Engineering and Technology for Computerized Dentistry Ministry of Health &amp; NMPA Key Laboratory for Dental Materials  Beijing 100081 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Orthodontics Peking University School and Hospital of Stomatology  Beijing 100081 China"},{"name":"National Center of Stomatology &amp; National Clinical Research Center for Oral Diseases &amp; National Engineering Laboratory for Digital and Material Technology of Stomatology &amp; Beijing Key Laboratory for Digital Stomatology &amp; Research Center of Engineering and Technology for Computerized Dentistry Ministry of Health &amp; NMPA Key Laboratory for Dental Materials  Beijing 100081 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanheng","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Orthodontics Peking University School and Hospital of Stomatology  Beijing 100081 China"},{"name":"National Center of Stomatology &amp; National Clinical Research Center for Oral Diseases &amp; National Engineering Laboratory for Digital and Material Technology of Stomatology &amp; Beijing Key Laboratory for Digital Stomatology &amp; Research Center of Engineering and Technology for Computerized Dentistry Ministry of Health &amp; NMPA Key Laboratory for Dental Materials  Beijing 100081 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3926-1999","authenticated-orcid":false,"given":"Xing","family":"Wang","sequence":"additional","affiliation":[{"name":"Beijing National Laboratory for Molecular Sciences Institute of Chemistry Chinese Academy of Sciences  Beijing 100190 China"},{"name":"University of Chinese Academy of Sciences  Beijing 100049 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7625-4600","authenticated-orcid":false,"given":"Dawei","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Orthodontics Peking University School and Hospital of Stomatology  Beijing 100081 China"},{"name":"National Center of Stomatology &amp; National Clinical Research Center for Oral Diseases &amp; National Engineering Laboratory for Digital and Material Technology of Stomatology &amp; Beijing Key Laboratory for Digital Stomatology &amp; Research Center of Engineering and Technology for Computerized Dentistry Ministry of Health &amp; NMPA Key Laboratory for Dental Materials  Beijing 100081 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,3,9]]},"reference":[{"key":"e_1_2_8_1_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmat1866"},{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/BOT.0000000000000978"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2009.228"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2020.00445"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.msec.2019.01.075"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202203734"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2021.121114"},{"key":"e_1_2_8_6_2","first-page":"65","volume":"9","author":"Xiong Y.","year":"2022","journal-title":"Med"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10439-021-02832-w"},{"key":"e_1_2_8_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202004172"},{"key":"e_1_2_8_7_3","doi-asserted-by":"publisher","DOI":"10.1089\/ten.teb.2011.0182"},{"key":"e_1_2_8_7_4","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.201801106"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.1c09889"},{"key":"e_1_2_8_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202209041"},{"key":"e_1_2_8_8_3","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics15010150"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23073665"},{"key":"e_1_2_8_9_2","doi-asserted-by":"publisher","DOI":"10.34133\/research.0089"},{"key":"e_1_2_8_9_3","doi-asserted-by":"publisher","DOI":"10.1016\/j.msec.2020.110862"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23031806"},{"key":"e_1_2_8_10_2","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2020.00047"},{"key":"e_1_2_8_10_3","doi-asserted-by":"publisher","DOI":"10.1016\/j.tem.2017.11.008"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.biomac.0c01085"},{"key":"e_1_2_8_11_2","doi-asserted-by":"publisher","DOI":"10.1088\/1748-605X\/aabb31"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2021.09.033"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2021.06.022"},{"key":"e_1_2_8_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201901580"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.3389\/fchem.2019.00682"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/cac2.12272"},{"key":"e_1_2_8_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00011-022-01563-5"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.7150\/ijms.61080"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2021.121239"},{"key":"e_1_2_8_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2022.10.024"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.6b03064"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1039\/D0BM00376J"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carres.2005.07.022"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2012.113"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2021.04.052"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2014.02.012"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2017.12.025"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41422-018-0070-2"},{"key":"e_1_2_8_25_2","doi-asserted-by":"publisher","DOI":"10.3390\/cells11233879"},{"key":"e_1_2_8_25_3","doi-asserted-by":"publisher","DOI":"10.1177\/00220345211068338"}],"container-title":["Advanced Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/advs.202306924","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/advs.202306924","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/advs.202306924","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T15:05:42Z","timestamp":1777561542000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/advs.202306924"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3,9]]},"references-count":42,"journal-issue":{"issue":"20","published-print":{"date-parts":[[2024,5]]}},"alternative-id":["10.1002\/advs.202306924"],"URL":"https:\/\/doi.org\/10.1002\/advs.202306924","archive":["Portico"],"relation":{},"ISSN":["2198-3844","2198-3844"],"issn-type":[{"value":"2198-3844","type":"print"},{"value":"2198-3844","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,3,9]]},"assertion":[{"value":"2023-09-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-03-09","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"2306924"}}