{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T01:35:18Z","timestamp":1775698518614,"version":"3.50.1"},"reference-count":62,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2024,1,8]],"date-time":"2024-01-08T00:00:00Z","timestamp":1704672000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000070","name":"National Institute of Biomedical Imaging and Bioengineering","doi-asserted-by":"publisher","award":["Intramural Research Program"],"award-info":[{"award-number":["Intramural Research Program"]}],"id":[{"id":"10.13039\/100000070","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Due to the limited capacity of mammals to regenerate complex tissues, researchers have worked to understand the mechanisms of tissue regeneration in organisms that maintain that capacity. One example is the MRL\/MpJ mouse strain with unique regenerative capacity in ear pinnae that is absent from other strains, such as the common C57BL\/6 strain. The MRL\/MpJ mouse has also been associated with an autoimmune phenotype even in the absence of the mutant <jats:italic>Fas<\/jats:italic> gene described in its parent strain MRL\/lpr. Due to these findings, the differences between the responses of MRL\/MpJ versus C57BL\/6 strain are evaluated in volumetric muscle injury and subsequent material implantation. One salient feature of the MRL\/MpJ response to injury is robust adipogenesis within the muscle. This is associated with a decrease in M2\u2010like polarization in response to biologically derived extracellular matrix scaffolds. In pro\u2010fibrotic materials, such as polyethylene, there are fewer foreign body giant cells in the MRL\/MpJ mice. As there are reports of both positive and negative influences of adipose tissue and adipogenesis on wound healing, this model can provide an important lens to investigate the interplay between stem cells, adipose tissue, and immune responses in trauma and material implantation.<\/jats:p>","DOI":"10.1002\/advs.202306961","type":"journal-article","created":{"date-parts":[[2024,1,9]],"date-time":"2024-01-09T02:00:15Z","timestamp":1704765615000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Intersection of Immunity, Metabolism, and Muscle Regeneration in an Autoimmune\u2010Prone MRL Mouse Model"],"prefix":"10.1002","volume":"11","author":[{"given":"Tran B.","family":"Ngo","sequence":"first","affiliation":[{"name":"Section on Immunoengineering Center for Biomedical Engineering and Technology Acceleration National Institute of Biomedical Imaging and Bioengineering National Institutes of Health  Bethesda MD 20814 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aditya","family":"Josyula","sequence":"additional","affiliation":[{"name":"Section on Immunoengineering Center for Biomedical Engineering and Technology Acceleration National Institute of Biomedical Imaging and Bioengineering National Institutes of Health  Bethesda MD 20814 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sabrina","family":"DeStefano","sequence":"additional","affiliation":[{"name":"Section on Immunoengineering Center for Biomedical Engineering and Technology Acceleration National Institute of Biomedical Imaging and Bioengineering National Institutes of Health  Bethesda MD 20814 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daphna","family":"Fertil","sequence":"additional","affiliation":[{"name":"Section on Immunoengineering Center for Biomedical Engineering and Technology Acceleration National Institute of Biomedical Imaging and Bioengineering National Institutes of Health  Bethesda MD 20814 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mondreakest","family":"Faust","sequence":"additional","affiliation":[{"name":"Section on Immunoengineering Center for Biomedical Engineering and Technology Acceleration National Institute of Biomedical Imaging and Bioengineering National Institutes of Health  Bethesda MD 20814 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ravi","family":"Lokwani","sequence":"additional","affiliation":[{"name":"Section on Immunoengineering Center for Biomedical Engineering and Technology Acceleration National Institute of Biomedical Imaging and Bioengineering National Institutes of Health  Bethesda MD 20814 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2587-8330","authenticated-orcid":false,"given":"Kaitlyn","family":"Sadtler","sequence":"additional","affiliation":[{"name":"Section on Immunoengineering Center for Biomedical Engineering and Technology Acceleration National Institute of Biomedical Imaging and Bioengineering National Institutes of Health  Bethesda MD 20814 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,1,8]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"publisher","DOI":"10.1002\/jez.b.22925"},{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2017.08.007"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-39506-1"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.13847"},{"key":"e_1_2_9_5_1","first-page":"71","volume":"61","author":"Godwin J. W.","year":"2017","journal-title":"Developmental Biology"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11515-012-1192-4"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-475X.2005.00092.x"},{"key":"e_1_2_9_7_2","first-page":"547","volume":"209","author":"Beare A. H. M.","year":"2006","journal-title":"Kaibogaku Zasshi"},{"key":"e_1_2_9_7_3","doi-asserted-by":"publisher","DOI":"10.1002\/dvdy.10243"},{"key":"e_1_2_9_8_1","first-page":"163","volume":"218","author":"Buckley G.","year":"2011","journal-title":"Kaibogaku Zasshi"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2020.00022"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-021-00635-7"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2014.09.007"},{"key":"e_1_2_9_12_1","first-page":"16","author":"Podolak\u2010Popinigis J.","year":"2015","journal-title":"BMC Genomics"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.12154"},{"key":"e_1_2_9_13_2","doi-asserted-by":"publisher","DOI":"10.1530\/JOE-16-0229"},{"key":"e_1_2_9_13_3","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2017.00475"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-68971-7"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2018.11.002"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/npjregenmed.2016.8"},{"key":"e_1_2_9_16_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3008085"},{"key":"e_1_2_9_16_3","doi-asserted-by":"publisher","DOI":"10.2522\/ptj.20150133"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.J.00287"},{"key":"e_1_2_9_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-4636(200101)54:1<12::AID-JBM2>3.0.CO;2-X"},{"key":"e_1_2_9_17_3","doi-asserted-by":"publisher","DOI":"10.1016\/j.orthres.2004.08.023"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aad9272"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btw535"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkac1000"},{"key":"e_1_2_9_21_1","author":"Sapru S.","year":"2022","journal-title":"ACS Biomater. Sci. Eng."},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1067-1927.2005.130212.x"},{"key":"e_1_2_9_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.carpath.2014.06.001"},{"key":"e_1_2_9_22_3","first-page":"785","volume":"359","author":"Heber\u2013Katz E.","year":"2004","journal-title":"Series B: Biolog. Sci."},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1177\/0961203308097479"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/BCR.0b013e318233fad6"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/s42003-023-04790-6"},{"key":"e_1_2_9_25_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-34191-y"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00735.2009"},{"key":"e_1_2_9_26_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1103180"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.820291014"},{"key":"e_1_2_9_27_2","doi-asserted-by":"publisher","DOI":"10.3390\/ma8095269"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2020.00069"},{"key":"e_1_2_9_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2021.06.026"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21197229"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/imm.12844"},{"key":"e_1_2_9_31_1","doi-asserted-by":"crossref","unstructured":"F. M.Wensveen S.Valenti\u0107 M.\u0160estan T. T.Wensveen B.Poli\u0107 Seminars in immunology2015 27 322.","DOI":"10.1016\/j.smim.2015.10.006"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coph.2020.04.003"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2004-0503"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/term.1688"},{"key":"e_1_2_9_35_1","unstructured":"S.DeStefano A.Josyula M.Faust D.Fertil R.Lokwani T. B.Ngo K.Sadtler bioRxiv 2023 2023.08. 15.553390."},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(03)00319-2"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2016.01.009"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.20.11792"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2013.10.054"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.536326"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-34532-x"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2018.08.018"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.gene.6364286"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.181329398"},{"key":"e_1_2_9_45_1","author":"Lokwani R.","year":"2023","journal-title":"Nat. Mater."},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1089\/ten.tea.2016.0304"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbiomech.2021.110770"},{"key":"e_1_2_9_48_1","unstructured":"J. R.Wang F. P. M.deVillena L.McMillan presented atBMC Bioinformatics 2012."}],"container-title":["Advanced Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/advs.202306961","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T18:54:22Z","timestamp":1759776862000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/advs.202306961"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1,8]]},"references-count":62,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2024,3]]}},"alternative-id":["10.1002\/advs.202306961"],"URL":"https:\/\/doi.org\/10.1002\/advs.202306961","archive":["Portico"],"relation":{},"ISSN":["2198-3844","2198-3844"],"issn-type":[{"value":"2198-3844","type":"print"},{"value":"2198-3844","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1,8]]},"assertion":[{"value":"2023-10-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-01-08","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"2306961"}}