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Hence, smart biodegradable biomaterials that provide effective and precise local anti\u2010infection effects and can promote the repair of bone defects are actively being developed. Here, a novel nano\u2010micro composite is fabricated by combining calcium phosphate (CaP) nanosheets with drug\u2010loaded GelMA microspheres via microfluidic technology. The microspheres are covalently linked with vancomycin (Van) through an oligonucleotide (oligo) linker using an EDC\/NHS carboxyl activator. Accordingly, a smart nano\u2010micro composite called \u201cCaP@MS\u2010Oligo\u2010Van\u201d is synthesized. The porous CaP@MS\u2010Oligo\u2010Van composites can target and capture bacteria. They can also release Van in response to the presence of bacterial micrococcal nuclease and Ca\n                    <jats:sup>2+<\/jats:sup>\n                    , exerting additional antibacterial effects and inhibiting the inflammatory response. Finally, the released CaP nanosheets can promote bone tissue repair. Overall, the findings show that a rapid, targeted drug release system based on CaP@MS\u2010Oligo\u2010Van can effectively target bone tissue infections. Hence, this agent holds potential in the clinical treatment of osteomyelitis caused by MRSA.\n                  <\/jats:p>","DOI":"10.1002\/advs.202306964","type":"journal-article","created":{"date-parts":[[2024,1,18]],"date-time":"2024-01-18T02:55:51Z","timestamp":1705546551000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Injectable Nano\u2010Micro Composites with Anti\u2010bacterial and Osteogenic Capabilities for Minimally Invasive Treatment of Osteomyelitis"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-9660-4901","authenticated-orcid":false,"given":"Guanghua","family":"Lu","sequence":"first","affiliation":[{"name":"Department of Orthopaedics Shanghai Tenth People's Hospital Tongji University School of Medicine  Shanghai 200072 P. R. 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