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To delay the process of vascular aging, anti\u2010inflammation may be an effective measure. The anti\u2010inflammatory factor annexin A1 (ANXA1) is shown to participate in several age\u2010related diseases; however, its function during vascular aging remains unclear. Here, an ANXA1 knockout (ANXA1\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    ) and an endothelial cell\u2010specific ANXA1 deletion\u00a0mouse (ANXA1\n                    <jats:sup>\u25b3EC<\/jats:sup>\n                    ) model are used to investigate the role of ANXA1 in vascular aging. ANXA1 depletion exacerbates vascular remodeling and dysfunction while upregulates\u00a0age\u2010 and inflammation\u2010related protein expression. Conversely,\u00a0Ac2\u201026 (a mimetic peptide of ANXA1) supplementation reverses this phenomenon. Furthermore, long\u2010term tumor necrosis factor\u2010alpha (TNF\u2010\u03b1) induction of human umbilical vein endothelial cells (HUVECs) increases cell senescence. Finally, the senescence\u2010associated secretory phenotype and senescence\u2010related protein expression, rates of senescence\u2010\u03b2\u2010galactosidase\u00a0positivity, cell cycle arrest, cell migration, and tube formation ability are observed in both ANXA1\u2010knockdown HUVECs and overexpressed ANXA1\u2010TNF\u2010\u03b1 induced senescent HUVECs. They also explore the impact of formyl\u00a0peptide receptor 2 (a receptor of ANXA1) in an ANXA1 overexpression inflammatory model. These data provide compelling evidence that age\u2010related inflammation in arteries contributes to senescent endothelial cells that promote vascular aging.\n                  <\/jats:p>","DOI":"10.1002\/advs.202307040","type":"journal-article","created":{"date-parts":[[2024,2,15]],"date-time":"2024-02-15T06:25:35Z","timestamp":1707978335000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Loss of Endothelial Annexin A1 Aggravates Inflammation\u2010Induched Vascular Aging"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8042-6532","authenticated-orcid":false,"given":"Qinyi","family":"You","sequence":"first","affiliation":[{"name":"Department of Geriatrics Fujian Medical University Union Hospital Fujian Key Laboratory of Vascular Aging (Fujian Medical University) Fujian Institute of Geriatrics Department of Cardiology Fujian Heart Disease Center Fujian Clinical Research Center 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