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Several SA derivatives and associated modification are identified, whereas the range and modes of action of SA\u2010related metabolites remain elusive. Here, the study discovered 2,4\u2010dihydroxybenzoic acid (2,4\u2010DHBA) and its glycosylated form as native SA derivatives in plants whose accumulation is largely induced by SA application and <jats:italic>Ps<\/jats:italic>. <jats:italic>camelliae\u2010sinensis<\/jats:italic> (<jats:italic>Pcs<\/jats:italic>) infection. CsSH1, a 4\/5\u2010hydroxylase, catalyzes the hydroxylation of SA to 2,4\u2010DHBA, and UDP\u2010glucosyltransferase UGT95B17 catalyzes the formation of 2,4\u2010DHBA glucoside. Down\u2010regulation reduced the accumulation of 2,4\u2010DHBA glucosides and enhanced the sensitivity of tea plants to <jats:italic>Pcs<\/jats:italic>. Conversely, overexpression of <jats:italic>UGT95B17<\/jats:italic> increased plant disease resistance. The exogenous application of 2,4\u2010DHBA and 2,5\u2010DHBA, as well as the accumulation of DHBA and plant resistance comparison, indicate that 2,4\u2010DHBA functions as a potentially bioactive molecule and is stored mainly as a glucose conjugate in tea plants, differs from the mechanism described in <jats:italic>Arabidopsis<\/jats:italic>. When 2,4\u2010DHBA is applied exogenously, <jats:italic>UGT95B17<\/jats:italic>\u2010silenced tea plants accumulated more 2,4\u2010DHBA than SA and showed induced resistance to <jats:italic>Pcs<\/jats:italic> infection. These results indicate that 2,4\u2010DHBA glucosylation positively regulates disease resistance and highlight the role of 2,4\u2010DHBA as potentially bioactive molecule in the establishment of basal resistance in tea plants.<\/jats:p>","DOI":"10.1002\/advs.202307051","type":"journal-article","created":{"date-parts":[[2023,12,8]],"date-time":"2023-12-08T11:52:10Z","timestamp":1702036330000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["2,4\u2010Dihydroxybenzoic Acid, a Novel SA Derivative, Controls Plant Immunity via UGT95B17\u2010Mediated Glucosylation: A Case Study in <i>Camellia Sinensis<\/i>"],"prefix":"10.1002","volume":"11","author":[{"given":"Mengqian","family":"Lu","sequence":"first","affiliation":[{"name":"State Key Laboratory of Tea Plant Biology and Utilization International Joint Laboratory on Tea Chemistry and Health Effects Anhui Agricultural University  Hefei Anhui 230036 P. R. 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