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However, current anti\u2010stenosis drug\u2010eluting stents face challenges due to their limited functions and long\u2010term safety concerns, significantly compromising their therapeutic effect. Herein, a stent\u2010free anti\u2010stenosis drug coating (denoted as Cur\u2010NO\u2010Gel) based on a peptide hydrogel is proposed. This hydrogel is formed by assembling a nitric oxide (NO) donor\u2010peptide conjugate as a hydrogelator and encapsulating curcumin (Cur) during the assembly process. Cur\u2010NO\u2010Gel has the capability to release NO upon \u03b2\u2010galactosidase stimulation and gradually release Cur through hydrogel hydrolysis. The in vitro experiments confirmed that Cur\u2010NO\u2010Gel protects vascular endothelial cells against oxidative stress injury, inhibits cellular activation of vascular smooth muscle cells, and suppresses adventitial fibroblasts. Moreover, periadventitial administration of Cur\u2010NO\u2010Gel in the angioplasty model demonstrate its ability to inhibit vascular stenosis by promoting reendothelialization, suppressing neointima hyperplasia, and preventing constrictive remodeling. 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