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Here it is reported that the RNA\u2010binding protein RBMS1 is positively associated with increased lymph node metastasis in non\u2010small cell lung cancer (NSCLC). Depletion of RBMS1 suppresses cancer cell migration and invasion in vitro and inhibits cancer cell metastasis in vivo. Mechanistically, RBMS1 interacts with YTHDF1 to promote the translation of S100P, thereby accelerating NSCLC cell metastasis. The RRM2 motif of RBMS1 and the YTH domain of YTHDF1 are required for the binding of RBMS1 and YTHDF1. RBMS1 ablation inhibits the translation of S100P and suppresses tumor metastasis. Targeting RBMS1 with NTP, a small molecular chemical inhibitor of RBMS1, attenuates tumor metastasis in a mouse lung metastasis model. Correlation studies in lung cancer patients further validate the clinical relevance of the findings. Collectively, the study provides insight into the molecular mechanism by which RBMS1 promotes NSCLC metastasis and offers a therapeutic strategy for metastatic NSCLC.<\/jats:p>","DOI":"10.1002\/advs.202307122","type":"journal-article","created":{"date-parts":[[2024,2,11]],"date-time":"2024-02-11T21:25:30Z","timestamp":1707686730000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["RBMS1 Coordinates with the m\n                    <sup>6<\/sup>\n                    A Reader YTHDF1 to Promote NSCLC Metastasis through Stimulating S100P Translation"],"prefix":"10.1002","volume":"11","author":[{"given":"Yu","family":"Sun","sequence":"first","affiliation":[{"name":"Sino\u2010US Research Center for Cancer Translational Medicine of the Second Affiliated Hospital of Dalian Medical University &amp; Institute of Cancer Stem Cell Dalian Medical University  Dalian 116023 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Pathology the First Affiliated Hospital of Dalian Medical University Dalian Medical University  Dalian 116011 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siwen","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Oncology &amp; 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