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Consequently, recent research for myocardial infarction (MI) therapy has utilized hdECM with various delivery techniques, such as injection or patch implantation. In this study, a novel approach for hdECM delivery using a wet adhesive paintable hydrogel is proposed. The hdECM\u2010containing paintable hydrogel (pdHA_t) is simply applied, with no theoretical limit to the size or shape, making it highly beneficial for scale\u2010up. Additionally, pdHA_t exhibits robust adhesion to the epicardium, with a minimal swelling ratio and sufficient adhesion strength for MI treatment when applied to the rat MI model. Moreover, the adhesiveness of pdHA_t can be easily washed off to prevent undesired adhesion with nearby organs, such as the rib cages and lungs, which can result in stenosis. During the 28 days of in vivo analysis, the pdHA_t not only facilitates functional regeneration by reducing ventricular wall thinning but also promotes neo\u2010vascularization in the MI region. In conclusion, the pdHA_t presents a promising strategy for MI treatment and cardiac tissue regeneration, offering the potential for improved patient outcomes and enhanced cardiac function post\u2010MI.<\/jats:p>","DOI":"10.1002\/advs.202307353","type":"journal-article","created":{"date-parts":[[2024,3,19]],"date-time":"2024-03-19T15:46:57Z","timestamp":1710863217000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Paintable Decellularized\u2010ECM Hydrogel for Preventing Cardiac Tissue Damage"],"prefix":"10.1002","volume":"11","author":[{"given":"Jaewoo","family":"Lee","sequence":"first","affiliation":[{"name":"School of Chemical and Biological Engineering, Institute of Chemical Processes Seoul National University  Seoul 151\u2013742 Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seul\u2010Gi","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Stem Cell Biology School of Medicine Konkuk University  Seoul 143\u2013701 Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beom\u2010seok","family":"Kim","sequence":"additional","affiliation":[{"name":"Interdisciplinary Program in Bioengineering Seoul National University  Seoul 151\u2013742 Republic of Korea"},{"name":"Research Division EGC Therapeutics  Seoul 08790 Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinhye","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Stem Cell Biology School of Medicine Konkuk University  Seoul 143\u2013701 Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. 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