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It have been investigated that pharmacological activation of transient receptor potential vanilloid 1 (TRPV1) significantly alleviated cartilage degeneration by abolishing chondrocyte ferroptosis. In this work, in view of the thermal activated feature of TRPV1, Citrate\u2010stabilized gold nanorods (Cit\u2010AuNRs) is conjugated to TRPV1 monoclonal antibody (Cit\u2010AuNRs@Anti\u2010TRPV1) as a photothermal switch for TRPV1 activation in chondrocytes under near infrared (NIR) irradiation. The conjugation of TRPV1 monoclonal antibody barely affect the morphology and physicochemical properties of Cit\u2010AuNRs. Under NIR irradiation, Cit\u2010AuNRs@Anti\u2010TRPV1 exhibited good biocompatibility and flexible photothermal responsiveness. Intra\u2010articular injection of Cit\u2010AuNRs@Anti\u2010TRPV1 followed by NIR irradiation significantly activated TRPV1 and attenuated cartilage degradation by suppressing chondrocytes ferroptosis. The osteophyte formation and subchondral bone sclerosis are remarkably alleviated by NIR\u2010inspired Cit\u2010AuNRs@Anti\u2010TRPV1. Furthermore, the activation of TRPV1 by Cit\u2010AuNRs@Anti\u2010TRPV1 evidently improved physical activities and alleviated pain of destabilization of the medial meniscus (DMM)\u2010induced OA mice. The study reveals Cit\u2010AuNRs@Anti\u2010TRPV1 under NIR irradiation protects chondrocytes from ferroptosis and attenuates OA progression, providing a potential therapeutic strategy for the treatment of OA.<\/jats:p>","DOI":"10.1002\/advs.202307683","type":"journal-article","created":{"date-parts":[[2024,2,15]],"date-time":"2024-02-15T07:14:42Z","timestamp":1707981282000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["Near Infrared Responsive Gold Nanorods Attenuate Osteoarthritis Progression by Targeting TRPV1"],"prefix":"10.1002","volume":"11","author":[{"given":"Weitong","family":"Li","sequence":"first","affiliation":[{"name":"Division of Sports Medicine and Adult Reconstructive Surgery Department of Orthopedic Surgery Nanjing Drum Tower Hospital Clinical College of Nanjing University of Chinese Medicine  321 Zhongshan Road Nanjing Jiangsu 210008 China"},{"name":"Division of Sports Medicine and Adult 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