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Here, it is shown that the nasal secretions of ECRS patients have high eosinophil extracellular trap (EET) and cell\u2010free DNA (cfDNA) levels. Moreover, the cfDNA induced EET formation by activating toll\u2010like receptor 9 (TLR9) signaling. After demonstrating that DNase I reduced eosinophilic inflammation by modulating EET formation, linear polyglycerol\u2010amine (LPG\n                    <jats:sub>A<\/jats:sub>\n                    )\u2010coated TiS\n                    <jats:sub>2<\/jats:sub>\n                    nanosheets (TLPG\n                    <jats:sub>A<\/jats:sub>\n                    ) as functional 2D nanoplatforms with low cytotoxicity, mild protein adsorption, and increased degradation rate is developed. Due to the more flexible linear architecture, TLPG\n                    <jats:sub>A<\/jats:sub>\n                    exhibited higher cfDNA affinity than the TiS\n                    <jats:sub>2<\/jats:sub>\n                    nanosheets coated with dendritic polyglycerol\u2010amine (TDPG\n                    <jats:sub>A<\/jats:sub>\n                    ). TLPG\n                    <jats:sub>A<\/jats:sub>\n                    reduced cfDNA levels in the nasal secretions of ECRS patients while suppressing cfDNA\u2010induced TLR9 activation and EET formation in vitro. TLPG\n                    <jats:sub>A<\/jats:sub>\n                    displayed exceptional biocompatibility, preferential nasal localization, and potent inflammation modulation in mice with eosinophilic inflammation. These results highlight the pivotal feature of the linear molecular architecture and 2D sheet\u2010like nanostructure in the development of anti\u2010inflammation nanoplatforms, which can be exploited for ECRS treatment.\n                  <\/jats:p>","DOI":"10.1002\/advs.202307800","type":"journal-article","created":{"date-parts":[[2024,3,13]],"date-time":"2024-03-13T08:39:25Z","timestamp":1710319165000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Functional 2D Nanoplatforms Alleviate Eosinophilic Chronic Rhinosinusitis by Modulating Eosinophil Extracellular Trap Formation"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7020-5325","authenticated-orcid":false,"given":"Zhaoxu","family":"Tu","sequence":"first","affiliation":[{"name":"Department of Otolaryngology The Sixth Affiliated Hospital Sun Yat\u2010sen University  Guangzhou Guangdong 510655 China"},{"name":"Department of Otolaryngology The First Affiliated Hospital Sun Yat\u2010sen University  Guangzhou Guangdong 510655 China"},{"name":"Biomedical Innovation Center The Sixth Affiliated Hospital Sun Yat\u2010sen University  Guangzhou Guangdong 510655 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology The Sixth Affiliated Hospital Sun Yat\u2010sen University  Guangzhou Guangdong 510655 China"},{"name":"Biomedical Innovation Center The Sixth Affiliated Hospital Sun Yat\u2010sen University  Guangzhou Guangdong 510655 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changyi","family":"Xu","sequence":"additional","affiliation":[{"name":"Biomedical Innovation Center The Sixth Affiliated Hospital Sun Yat\u2010sen University  Guangzhou Guangdong 510655 China"},{"name":"Department of Clinical Laboratory The Sixth Affiliated Hospital Sun Yat\u2010sen University  Guangzhou Guangdong 510655 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology The First Affiliated Hospital Sun Yat\u2010sen University  Guangzhou Guangdong 510655 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tong","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology The First Affiliated Hospital Sun Yat\u2010sen University  Guangzhou Guangdong 510655 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongqiang","family":"Xiao","sequence":"additional","affiliation":[{"name":"ENT institute Eye &amp; ENT Hospital Fudan University  Shanghai 201114 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongxia","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology The Sixth Affiliated Hospital Sun Yat\u2010sen University  Guangzhou Guangdong 510655 China"},{"name":"Biomedical Innovation Center The Sixth Affiliated Hospital Sun Yat\u2010sen University  Guangzhou Guangdong 510655 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuaiyin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology The Sixth Affiliated Hospital Sun Yat\u2010sen University  Guangzhou Guangdong 510655 China"},{"name":"Biomedical Innovation Center The Sixth Affiliated Hospital Sun Yat\u2010sen University  Guangzhou Guangdong 510655 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinran","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology The Sixth Affiliated Hospital Sun Yat\u2010sen University  Guangzhou Guangdong 510655 China"},{"name":"Biomedical Innovation Center The Sixth Affiliated Hospital Sun Yat\u2010sen University  Guangzhou Guangdong 510655 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology The First Affiliated Hospital Sun Yat\u2010sen University  Guangzhou Guangdong 510655 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiping","family":"Wen","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology The Sixth Affiliated Hospital Sun Yat\u2010sen University  Guangzhou Guangdong 510655 China"},{"name":"Department of Otolaryngology The First Affiliated Hospital Sun Yat\u2010sen University  Guangzhou Guangdong 510655 China"},{"name":"Biomedical Innovation Center The Sixth Affiliated Hospital Sun Yat\u2010sen University  Guangzhou Guangdong 510655 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,3,13]]},"reference":[{"key":"e_1_2_8_1_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-020-00218-1"},{"key":"e_1_2_8_2_1","first-page":"1395","volume":"10","author":"Sedaghat A. 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