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Previously, growing evidence indicated that quorum sensing (QS), a chemical communication signal among bacterial cells, can accelerate resistance under evolutionary pressure. This study aims to develop a medical dressing to treat PTO by inhibiting QS and regulating the inflammatory microenvironment, which includes severe oxidative stress and acid abscesses, through a reactive oxygen species (ROS)\u2010responsive bond between N1\u2010 (4\u2010borobenzoyl)\u2010N3\u2010(4\u2010borobenzoyl)\u2010the N1, the N1, N3, N3\u2010tetramethylpropane\u20101,3\u2010diamine (TSPBA) and polyvinyl alcohol (PVA), and the amino side chain of hyperbranched polylysine (HBPL). Physically enclosed QS inhibitors subsequently exerted the antibacterial effects. This hydrogel can scavenge hydrogen peroxide (H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    ), superoxide anion free radical (\u00b7O\n                    <jats:sub>2<\/jats:sub>\n                    <jats:sup>\u2212<\/jats:sup>\n                    ), hydroxyl radicals (\u00b7OH) and 2,2\u2010di(4\u2010tert\u2010octylphenyl)\u20101\u2010picryl\u2010hydrazyl (DPPH) to reduce oxidative stress and inhibit \u201cbacteria\u2010to\u2010bacteria communication\u201d, thus clearing planktonic bacteria and biofilms, accelerating bacterial plasmolysis, reducing bacterial virulence and interfering with membrane transport. After in vivo treatment with hydrogel, nearly all bacteria are eliminated, inflammation is effectively inhibited, and osteogenesis and bone repair are promoted to facilitate recovery from PTO. The work demonstrates the clinical translational potential of the hydrogel in the treatment of drug\u2010resistant bacteria induced PTO.\n                  <\/jats:p>","DOI":"10.1002\/advs.202307969","type":"journal-article","created":{"date-parts":[[2024,3,14]],"date-time":"2024-03-14T05:19:35Z","timestamp":1710393575000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["Inflammatory Microenvironment\u2010Responsive Hydrogels Enclosed with Quorum Sensing Inhibitor for Treating Post\u2010Traumatic Osteomyelitis"],"prefix":"10.1002","volume":"11","author":[{"given":"Wenting","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases The Second Affiliated Hospital Zhejiang University School of Medicine  Hangzhou Zhejiang 310009 China"},{"name":"Key Laboratory of Multiple Organ Failure (Zhejiang University), Ministry of Education  Hangzhou 310053 China"},{"name":"Research Center for Life Science and Human Health Binjiang Institute of Zhejiang University  Hangzhou 310053 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huidan","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases The Second Affiliated Hospital Zhejiang University School of Medicine  Hangzhou Zhejiang 310009 China"},{"name":"Key Laboratory of Multiple Organ Failure (Zhejiang University), Ministry of Education  Hangzhou 310053 China"},{"name":"Research Center for Life Science and Human Health Binjiang Institute of Zhejiang University  Hangzhou 310053 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanying","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases The Second Affiliated Hospital Zhejiang University School of Medicine  Hangzhou Zhejiang 310009 China"},{"name":"Key Laboratory of Multiple Organ Failure (Zhejiang University), Ministry of Education  Hangzhou 310053 China"},{"name":"Research Center for Life Science and Human Health Binjiang Institute of Zhejiang University  Hangzhou 310053 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiahao","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of General Surgery Sir Run\u2010Run Shaw Hospital Zhejiang University School of Medicine  Hangzhou Zhejiang 310016 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yifei","family":"Zeng","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases The Second Affiliated Hospital Zhejiang University School of Medicine  Hangzhou Zhejiang 310009 China"},{"name":"Key Laboratory of Multiple Organ Failure (Zhejiang University), Ministry of Education  Hangzhou 310053 China"},{"name":"Research Center for Life Science and Human Health Binjiang Institute of Zhejiang University  Hangzhou 310053 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiqun","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases The Second Affiliated Hospital Zhejiang University School of Medicine  Hangzhou Zhejiang 310009 China"},{"name":"Key Laboratory of Multiple Organ Failure (Zhejiang University), Ministry of Education  Hangzhou 310053 China"},{"name":"Research Center for Life Science and Human Health Binjiang Institute of Zhejiang University  Hangzhou 310053 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liyun","family":"Shi","sequence":"additional","affiliation":[{"name":"Institute of Translational Medicine Zhejiang Shuren University  Hangzhou Zhejiang 310015 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingyan","family":"Xia","sequence":"additional","affiliation":[{"name":"Department of Radiation Therapy The Second Affiliated Hospital Zhejiang University School of Medicine  Hangzhou Zhejiang 310009 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5764-6628","authenticated-orcid":false,"given":"Feng","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases The Second Affiliated Hospital Zhejiang University School of Medicine  Hangzhou Zhejiang 310009 China"},{"name":"Key Laboratory of Multiple Organ Failure (Zhejiang University), Ministry of Education  Hangzhou 310053 China"},{"name":"Research Center for Life Science and Human Health Binjiang Institute of Zhejiang University  Hangzhou 310053 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,3,14]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)16727-5"},{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.N.01350"},{"key":"e_1_2_9_3_1","first-page":"395","volume":"104","author":"Bury D. 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