{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T01:35:58Z","timestamp":1790213758081,"version":"4.1.0"},"reference-count":50,"publisher":"Wiley","issue":"16","license":[{"start":{"date-parts":[[2024,2,25]],"date-time":"2024-02-25T00:00:00Z","timestamp":1708819200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["52103188"],"award-info":[{"award-number":["52103188"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22175152"],"award-info":[{"award-number":["22175152"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFB3807300"],"award-info":[{"award-number":["2022YFB3807300"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["226\u20102022\u201000146"],"award-info":[{"award-number":["226\u20102022\u201000146"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The foreign body response (FBR) to implanted biomaterials and biomedical devices can severely impede their functionality and even lead to failure. The discovery of effective anti\u2010FBR materials remains a formidable challenge. Inspire by the enrichment of glutamic acid (E) and lysine (K) residues on human protein surfaces, a class of zwitterionic polypeptide (ZIP) hydrogels with alternating E and K sequences to mitigate the FBR is prepared. When subcutaneously implanted, the ZIP hydrogels caused minimal inflammation after 2 weeks and no obvious collagen capsulation after 6 months in mice. Importantly, these hydrogels effectively resisted the FBR in non\u2010human primate models for at least 2 months. In addition, the enzymatic degradability of the gel can be controlled by adjusting the crosslinking degree or the optical isomerism of amino acid monomers. The long\u2010term FBR resistance and controlled degradability of ZIP hydrogels open up new possibilities for a broad range of biomedical applications.<\/jats:p>","DOI":"10.1002\/advs.202308077","type":"journal-article","created":{"date-parts":[[2024,2,25]],"date-time":"2024-02-25T21:10:07Z","timestamp":1708895407000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Poly(Glutamic Acid\u2010Lysine) Hydrogels with Alternating Sequence Resist the Foreign Body Response in Rodents and Non\u2010Human Primates"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-4241-098X","authenticated-orcid":false,"given":"Xianchi","family":"Zhou","sequence":"first","affiliation":[{"name":"MOE Key Laboratory of Macromolecule Synthesis and Functionalization of Ministry of Education Department of Polymer Science and Engineering Zhejiang University  Hangzhou Zhejiang 310058 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenzhong","family":"Cao","sequence":"additional","affiliation":[{"name":"MOE Key Laboratory of Macromolecule Synthesis and Functionalization of Ministry of Education Department of Polymer Science and Engineering Zhejiang University  Hangzhou Zhejiang 310058 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongcheng","family":"Chen","sequence":"additional","affiliation":[{"name":"MOE Key Laboratory of Macromolecule Synthesis and Functionalization of Ministry of Education Department of Polymer Science and Engineering Zhejiang University  Hangzhou Zhejiang 310058 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zihao","family":"Zhu","sequence":"additional","affiliation":[{"name":"MOE Key Laboratory of Macromolecule Synthesis and Functionalization of Ministry of Education Department of Polymer Science and Engineering Zhejiang University  Hangzhou Zhejiang 310058 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yifeng","family":"Chen","sequence":"additional","affiliation":[{"name":"MOE Key Laboratory of Macromolecule Synthesis and Functionalization of Ministry of Education Department of Polymer Science and Engineering Zhejiang University  Hangzhou Zhejiang 310058 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanwen","family":"Ni","sequence":"additional","affiliation":[{"name":"MOE Key Laboratory of Macromolecule Synthesis and Functionalization of Ministry of Education Department of Polymer Science and Engineering Zhejiang University  Hangzhou Zhejiang 310058 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zuolong","family":"Liu","sequence":"additional","affiliation":[{"name":"MOE Key Laboratory of Macromolecule Synthesis and Functionalization of Ministry of Education Department of Polymer Science and Engineering Zhejiang University  Hangzhou Zhejiang 310058 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fan","family":"Jia","sequence":"additional","affiliation":[{"name":"Key Laboratory of Cardiovascular Intervention and Regenerative Medicine of Zhejiang Province Department of Cardiology Sir Run Run Shaw Hospital School of Medicine Zhejiang University  Hangzhou Zhejiang 310016 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhouyu","family":"Lu","sequence":"additional","affiliation":[{"name":"Eye Center The Second Affiliated Hospital School of Medicine Zhejiang Provincial Key Laboratory of Ophthalmology Zhejiang Provincial Clinical Research Center for Eye Diseases Zhejiang Provincial Engineering Institute on Eye Diseases Zhejiang University  Hangzhou Zhejiang 310009 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Ye","sequence":"additional","affiliation":[{"name":"Eye Center The Second Affiliated Hospital School of Medicine Zhejiang Provincial Key Laboratory of Ophthalmology Zhejiang Provincial Clinical Research Center for Eye Diseases Zhejiang Provincial Engineering Institute on Eye Diseases Zhejiang University  Hangzhou Zhejiang 310009 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haijie","family":"Han","sequence":"additional","affiliation":[{"name":"Eye Center The Second Affiliated Hospital School of Medicine Zhejiang Provincial Key Laboratory of Ophthalmology Zhejiang Provincial Clinical Research Center for Eye Diseases Zhejiang Provincial Engineering Institute on Eye Diseases Zhejiang University  Hangzhou Zhejiang 310009 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke","family":"Yao","sequence":"additional","affiliation":[{"name":"Eye Center The Second Affiliated Hospital School of Medicine Zhejiang Provincial Key Laboratory of Ophthalmology Zhejiang Provincial Clinical Research Center for Eye Diseases Zhejiang Provincial Engineering Institute on Eye Diseases Zhejiang University  Hangzhou Zhejiang 310009 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weifeng","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary and Pancreatic Surgery The Second Affiliated Hospital School of Medicine Zhejiang University  Hangzhou Zhejiang 310009 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyue","family":"Wei","sequence":"additional","affiliation":[{"name":"Key Laboratory of Biomass Chemical Engineering of Ministry of Education Department of Chemical and Biological Engineering Zhejiang University  Hangzhou Zhejiang 310058 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengfu","family":"Chen","sequence":"additional","affiliation":[{"name":"Key Laboratory of Biomass Chemical Engineering of Ministry of Education Department of Chemical and Biological Engineering Zhejiang University  Hangzhou Zhejiang 310058 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youxiang","family":"Wang","sequence":"additional","affiliation":[{"name":"MOE Key Laboratory of Macromolecule Synthesis and Functionalization of Ministry of Education Department of Polymer Science and Engineering Zhejiang University  Hangzhou Zhejiang 310058 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Ji","sequence":"additional","affiliation":[{"name":"MOE Key Laboratory of Macromolecule Synthesis and Functionalization of Ministry of Education Department of Polymer Science and Engineering Zhejiang University  Hangzhou Zhejiang 310058 P. R. China"},{"name":"International Research Center for X Polymers International Campus Zhejiang University  Haining Zhejiang 314400 P. R. China"},{"name":"State Key Laboratory of Transvascular Implantation Devices Zhejiang University  Hangzhou Zhejiang 311202 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5409-7480","authenticated-orcid":false,"given":"Peng","family":"Zhang","sequence":"additional","affiliation":[{"name":"MOE Key Laboratory of Macromolecule Synthesis and Functionalization of Ministry of Education Department of Polymer Science and Engineering Zhejiang University  Hangzhou Zhejiang 310058 P. R. China"},{"name":"International Research Center for X Polymers International Campus Zhejiang University  Haining Zhejiang 314400 P. R. China"},{"name":"State Key Laboratory of Transvascular Implantation Devices Zhejiang University  Hangzhou Zhejiang 311202 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,2,25]]},"reference":[{"key":"e_1_2_8_1_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41551-021-00739-4"},{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202209324"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aad2899"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41551-018-0275-1"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-13238-7"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.4030"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.smim.2007.11.004"},{"key":"e_1_2_8_7_2","first-page":"31","volume":"2020","author":"Zhang D.","year":"2008","journal-title":"Adv. Funct. Mater."},{"key":"e_1_2_8_7_3","first-page":"86","volume":"20","author":"Capuani S.","journal-title":"Semin. Immunol."},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202007226"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/btm2.10300"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202010929"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2019.08.010"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1039\/D3BM01783D"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2024.01.006"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-20314-w"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202000416"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aax3799"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.2c00344"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.2580"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abc5442"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aau7091"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2012491117"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202009431"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1039\/c2sc21135a"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202304594"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1080\/09205063.2014.941262"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2009.07.001"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1039\/C3TB21333A"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1116\/6.0002713"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsanm.2c03880"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.langmuir.1c00021"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1039\/C8RA00401C"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1039\/C6TB02407F"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nantod.2022.101674"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.langmuir.8b00810"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202004995"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.biomac.5b01031"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.langmuir.8b00851"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1080\/10717544.2023.2191891"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.langmuir.1c01945"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bios.2021.113477"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.snb.2022.133166"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10930-013-9505-2"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41551-021-00722-z"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmat4290"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1163\/156856208X386444"},{"key":"e_1_2_8_46_1","author":"Zhang E.","year":"2023","journal-title":"Nat. Biomed. Eng."},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1039\/D3BM00629H"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aax3799"}],"container-title":["Advanced Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/advs.202308077","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T15:48:21Z","timestamp":1759765701000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/advs.202308077"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,25]]},"references-count":50,"journal-issue":{"issue":"16","published-print":{"date-parts":[[2024,4]]}},"alternative-id":["10.1002\/advs.202308077"],"URL":"https:\/\/doi.org\/10.1002\/advs.202308077","archive":["Portico"],"relation":{},"ISSN":["2198-3844","2198-3844"],"issn-type":[{"value":"2198-3844","type":"print"},{"value":"2198-3844","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,2,25]]},"assertion":[{"value":"2023-10-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-02-25","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"2308077"}}