{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:25:00Z","timestamp":1786976700231,"version":"build-2736575974"},"reference-count":40,"publisher":"Wiley","issue":"18","license":[{"start":{"date-parts":[[2024,3,6]],"date-time":"2024-03-06T00:00:00Z","timestamp":1709683200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["MOST 110\u20102222\u2010E\u2010007\u2010011\u2010MY3"],"award-info":[{"award-number":["MOST 110\u20102222\u2010E\u2010007\u2010011\u2010MY3"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Tendon injuries resulting from accidents and aging are increasing globally. However, key tendon functional parameters such as microvascularity and oxygen perfusion remain inaccessible via the currently available clinical diagnostic tools, resulting in disagreements on optimal treatment options. Here, a new noninvasive method for anatomical and functional characterization of human tendons based on multispectral optoacoustic tomography (MSOT) is reported. Healthy subjects are investigated using a hand\u2010held scanner delivering real\u2010time volumetric images. Tendons in the wrist, ankle, and lower leg are imaged in the near\u2010infrared optical spectrum to utilize endogenous contrast from Type I collagen. Morphology of the flexor carpi ulnaris, carpi radialis, palmaris longus, and Achilles tendons are reconstructed in full. The functional roles of the flexor digitorium longus, hallicus longus, and the tibialis posterior tendons have been visualized by dynamic tracking during toe extension\u2010flexion motion. Furthermore, major vessels and microvasculature near the Achilles tendon are localized, and the global increase in oxygen saturation in response to targeted exercise is confirmed by perfusion studies. MSOT is shown to be a versatile tool capable of anatomical and functional tendon assessments. Future studies including abnormal subjects can validate the method as a viable noninvasive clinical tool for tendinopathy management and healing monitoring.<\/jats:p>","DOI":"10.1002\/advs.202308336","type":"journal-article","created":{"date-parts":[[2024,3,6]],"date-time":"2024-03-06T09:15:15Z","timestamp":1709716515000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Multispectral Optoacoustic Tomography Enables In Vivo Anatomical and Functional Assessment of Human Tendons"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0574-2826","authenticated-orcid":false,"given":"Ivana","family":"Ivankovic","sequence":"first","affiliation":[{"name":"Faculty of Medicine Institute for Biomedical Engineering and Institute of Pharmacology and Toxicology University of Zurich  Winterthurerstrasse 190 Zurich CH\u20108057 Switzerland"},{"name":"Department of Information Technology and Electrical Engineering Institute for Biomedical Engineering  ETH Zurich, Wolfgang\u2010Pauli\u2010Str. 27 Zurich CH\u20108093 Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1393-369X","authenticated-orcid":false,"given":"Hsiao\u2010Chun Amy","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University  No.101, Sec.2, Kuang\u2010Fu Rd Hsinchu 300044 Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8389-4924","authenticated-orcid":false,"given":"Ali","family":"\u00d6zbek","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Institute for Biomedical Engineering and Institute of Pharmacology and Toxicology University of Zurich  Winterthurerstrasse 190 Zurich CH\u20108057 Switzerland"},{"name":"Department of Information Technology and Electrical Engineering Institute for 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