{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T14:39:59Z","timestamp":1790347199396,"version":"4.1.0"},"reference-count":61,"publisher":"Wiley","issue":"21","license":[{"start":{"date-parts":[[2024,3,6]],"date-time":"2024-03-06T00:00:00Z","timestamp":1709683200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2019YFA0110500"],"award-info":[{"award-number":["2019YFA0110500"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82322046"],"award-info":[{"award-number":["82322046"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82020108020"],"award-info":[{"award-number":["82020108020"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82072198"],"award-info":[{"award-number":["82072198"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81873941"],"award-info":[{"award-number":["81873941"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>3D bioprinting techniques have enabled the fabrication of irregular large\u2010sized tissue engineering scaffolds. However, complicated customized designs increase the medical burden. Meanwhile, the integrated printing process hinders the cellular uniform distribution and local angiogenesis. A novel approach is introduced to the construction of sizable tissue engineering grafts by employing hydrogel 3D printing for modular bioadhesion assembly, and a poly (ethylene glycol) diacrylate (PEGDA)\u2010gelatin\u2010dopamine (PGD) hydrogel, photosensitive and adhesive, enabling fine microcage module fabrication via DLP 3D printing is developed. The PGD hydrogel printed micocages are flexible, allowing various shapes and cell\/tissue fillings for repairing diverse irregular tissue defects. In vivo experiments demonstrate robust vascularization and superior graft survival in nude mice. This assembly strategy based on scalable 3D printed hydrogel microcage module could simplify the construction of tissue with large volume and complex components, offering promise for diverse large tissue defect repairs.<\/jats:p>","DOI":"10.1002\/advs.202308381","type":"journal-article","created":{"date-parts":[[2024,3,6]],"date-time":"2024-03-06T17:24:25Z","timestamp":1709745865000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Clay Sculpture\u2010Inspired 3D Printed Microcage Module Using Bioadhesion Assembly for Specific\u2010Shaped Tissue Vascularization and Regeneration"],"prefix":"10.1002","volume":"11","author":[{"given":"Huimin","family":"Fang","sequence":"first","affiliation":[{"name":"Department of Plastic Surgery Union Hospital Tongji Medical College Huazhong University of Science and Technology  Wuhan 430022 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingyi","family":"Ju","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery Union Hospital Tongji Medical College Huazhong University of Science and Technology  Wuhan 430022 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lifeng","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery Union Hospital Tongji Medical College Huazhong University of Science and Technology  Wuhan 430022 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muran","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery Union Hospital Tongji Medical College Huazhong University of Science and Technology  Wuhan 430022 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guo","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery Union Hospital Tongji Medical College Huazhong University of Science and Technology  Wuhan 430022 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinfei","family":"Hou","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery Union Hospital Tongji Medical College Huazhong University of Science and Technology  Wuhan 430022 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenbin","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery Union Hospital Tongji Medical College Huazhong University of Science and Technology  Wuhan 430022 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenxing","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery Union Hospital Tongji Medical College Huazhong University of Science and Technology  Wuhan 430022 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4973-6636","authenticated-orcid":false,"given":"Jiaming","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery Union Hospital Tongji Medical College Huazhong University of Science and Technology  Wuhan 430022 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,3,6]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41584-019-0255-1"},{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202008681"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2021.03.003"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2018.11.008"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.34464"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.3413"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202201877"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtbio.2022.100539"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2019.07.043"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2021.09.005"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibtech.2018.05.009"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2016.03.010"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1089\/bioe.2020.0035"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.42006"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjps.2020.05.016"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2022.05.053"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202001736"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202302008"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature05968"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1080\/15583724.2022.2041032"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1039\/C9CS00285E"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.6b05318"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2021.01.033"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.201900275"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mser.2020.100543"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.compositesb.2022.109863"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.18063\/ijb.v4i1.126"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bprint.2020.e00116"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s42242-023-00245-3"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.18063\/ijb.758"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1088\/1758-5090\/ab6034"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1039\/D3BM01054F"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201704640"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcis.2023.04.150"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.201805964"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.201604894"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S386635"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2021.111782"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.201704195"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aba4261"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1039\/D1SM00483B"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.201801331"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.201910573"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtbio.2023.100799"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2022.06.036"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.msec.2019.110290"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abn5360"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.2c22359"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.a.37336"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2020.01.004"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.msec.2017.09.002"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gendis.2019.04.003"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcis.2020.04.040"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202000531"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1089\/ten.teb.2021.0004"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibtech.2016.03.002"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0000000000006046"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40824-022-00325-y"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2023.1126269"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hbpd.2022.10.007"},{"key":"e_1_2_9_61_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aau8355"}],"container-title":["Advanced Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/advs.202308381","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T22:09:52Z","timestamp":1759788592000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/advs.202308381"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3,6]]},"references-count":61,"journal-issue":{"issue":"21","published-print":{"date-parts":[[2024,6]]}},"alternative-id":["10.1002\/advs.202308381"],"URL":"https:\/\/doi.org\/10.1002\/advs.202308381","archive":["Portico"],"relation":{},"ISSN":["2198-3844","2198-3844"],"issn-type":[{"value":"2198-3844","type":"print"},{"value":"2198-3844","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,3,6]]},"assertion":[{"value":"2023-11-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-03-06","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"2308381"}}