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The weakening of pelvic connective tissues initiated by excessive collagen degradation is a leading cause of POP. However, the patches currently used in the clinic trigger an unfavorable inflammatory response, which often leads to implantation failure and the inability to simultaneously reverse progressive collagen degradation. Therefore, to overcome the present challenges, a new strategy is applied by introducing puerarin (Pue) into poly(<jats:sc>l<\/jats:sc>\u2010lactic acid) (PLLA) using electrospinning technology. PLLA improves the mechanical properties of the patch, while Pue offers intrinsic anti\u2010inflammatory and pro\u2010collagen synthesis effects. The results show that Pue is released from PLLA@Pue in a sustained manner for more than 20\u00a0days, with a total release rate exceeding 80%. The PLLA@Pue electrospun patches also show good biocompatibility and low cytotoxicity. The excellent anti\u2010inflammatory and pro\u2010collagen synthesis properties of the PLLA@Pue patch are demonstrated both in vitro in H<jats:sub>2<\/jats:sub>O<jats:sub>2<\/jats:sub>\u2010stimulated mouse fibroblasts and in vivo in rat abdominal wall muscle defects. Therefore, it is believed that this multifunctional electrospun patch integrating anti\u2010inflammatory and pro\u2010collagen synthesis properties can overcome the limitations of traditional patches and has great prospects for efficient pelvic floor reconstruction.<\/jats:p>","DOI":"10.1002\/advs.202308590","type":"journal-article","created":{"date-parts":[[2024,3,21]],"date-time":"2024-03-21T03:40:31Z","timestamp":1710992431000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Puerarin\u2010Loaded Electrospun Patches with Anti\u2010Inflammatory and Pro\u2010Collagen Synthesis Properties for Pelvic Floor Reconstruction"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3810-031X","authenticated-orcid":false,"given":"Di","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of General Surgery (Colorectal Surgery) Guangdong Provincial Key Laboratory of Colorectal 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