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This underscores the pivotal significance of oxidative stress in the damage inflicted upon retinal tissue. To combat ROS\u2010related challenges, this study focuses on creating an injectable and tissue\u2010adhesive hydrogel with tailored antioxidant properties for retinal applications. GelCA, a gelatin\u2010modified hydrogel with photo\u2010crosslinkable and injectable properties, is developed. To enhance its antioxidant capabilities, curcumin\u2010loaded polydopamine nanoparticles (Cur@PDA NPs) are incorporated into the GelCA matrix, resulting in a multifunctional nanocomposite hydrogel referred to as Cur@PDA@GelCA. This hydrogel exhibits excellent biocompatibility in both in vitro and in vivo assessments, along with enhanced tissue adhesion facilitated by NPs in an in vivo model. Importantly, Cur@PDA@GelCA demonstrates the potential to mitigate oxidative stress when administered via intravitreal injection in retinal injury models such as the optic nerve crush model. 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