{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T04:24:24Z","timestamp":1788668664501,"version":"build-2803163510"},"reference-count":59,"publisher":"Wiley","issue":"29","license":[{"start":{"date-parts":[[2024,6,11]],"date-time":"2024-06-11T00:00:00Z","timestamp":1718064000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["CB06\/05\/1105"],"award-info":[{"award-number":["CB06\/05\/1105"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["RD21\/0017\/0008"],"award-info":[{"award-number":["RD21\/0017\/0008"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011033","name":"Agencia Estatal de Investigaci\u00f3n","doi-asserted-by":"publisher","award":["PCI2018\u2010093029"],"award-info":[{"award-number":["PCI2018\u2010093029"]}],"id":[{"id":"10.13039\/501100011033","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011033","name":"Agencia Estatal de Investigaci\u00f3n","doi-asserted-by":"publisher","award":["PCI2021\u20101220752A"],"award-info":[{"award-number":["PCI2021\u20101220752A"]}],"id":[{"id":"10.13039\/501100011033","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011033","name":"Agencia Estatal de Investigaci\u00f3n","doi-asserted-by":"publisher","award":["PCI2021\u2010122095\u20102A"],"award-info":[{"award-number":["PCI2021\u2010122095\u20102A"]}],"id":[{"id":"10.13039\/501100011033","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011033","name":"Agencia Estatal de Investigaci\u00f3n","doi-asserted-by":"publisher","award":["CEX2021\u2010001214\u2010S"],"award-info":[{"award-number":["CEX2021\u2010001214\u2010S"]}],"id":[{"id":"10.13039\/501100011033","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Limb neuroprostheses aim to restore motor and sensory functions in amputated or severely nerve\u2010injured patients. These devices use neural interfaces to record and stimulate nerve action potentials, creating a bidirectional connection with the nervous system. Most neural interfaces are based on standard metal microelectrodes. In this work, a new generation of neural interfaces which replaces metals with engineered graphene, called EGNITE, is tested. In vitro and in vivo experiments are conducted to assess EGNITE biocompatibility. In vitro tests show that EGNITE does not impact cell viability. In vivo, no significant functional decrease or harmful effects are observed. Furthermore, the foreign body reaction to the intraneural implant is similar compared to other materials previously used in neural interfaces. Regarding functionality, EGNITE devices are able to stimulate nerve fascicles, during two months of implant, producing selective muscle activation with about three times less current compared to larger microelectrodes of standard materials. CNAP elicited by electrical stimuli and ENG evoked by mechanical stimuli are recorded with high resolution but are more affected by decreased functionality over time. This work constitutes further proof that graphene\u2010derived materials, and specifically EGNITE, is a promising conductive material of neural electrodes for advanced neuroprostheses.<\/jats:p>","DOI":"10.1002\/advs.202308689","type":"journal-article","created":{"date-parts":[[2024,6,12]],"date-time":"2024-06-12T02:41:00Z","timestamp":1718160060000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Engineered Graphene Material Improves the Performance of Intraneural Peripheral Nerve Electrodes"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0052-7446","authenticated-orcid":false,"given":"Bruno","family":"Rodr\u00edguez\u2010Meana","sequence":"first","affiliation":[{"name":"Institute of Neurosciences Department of Cell Biology Physiology and Immunology Universitat Aut\u00f2noma de Barcelona  Bellaterra 08193 Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red en Enfermedades Neurodegenerativas (CIBERNED) Instituto de Salud Carlos III  Madrid 28031 Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaume","family":"del Valle","sequence":"additional","affiliation":[{"name":"Institute of Neurosciences Department of Cell Biology Physiology and Immunology Universitat Aut\u00f2noma de Barcelona  Bellaterra 08193 Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red en Enfermedades Neurodegenerativas (CIBERNED) Instituto de Salud Carlos III  Madrid 28031 Spain"},{"name":"Department de Bioqu\u00edmica i Fisiologia Universitat de Barcelona  Barcelona 08028 Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dami\u00e0","family":"Viana","sequence":"additional","affiliation":[{"name":"Catalan Institute of Nanoscience and Nanotechnology (ICN2) CSIC and BIST Campus UAB  Bellaterra 08193 Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven T.","family":"Walston","sequence":"additional","affiliation":[{"name":"Catalan Institute of Nanoscience and Nanotechnology (ICN2) CSIC and BIST Campus UAB  Bellaterra 08193 Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola","family":"Ria","sequence":"additional","affiliation":[{"name":"Catalan Institute of Nanoscience and Nanotechnology (ICN2) CSIC and BIST Campus UAB  Bellaterra 08193 Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduard","family":"Masvidal\u2010Codina","sequence":"additional","affiliation":[{"name":"Catalan Institute of Nanoscience and Nanotechnology (ICN2) CSIC and BIST Campus UAB  Bellaterra 08193 Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose A.","family":"Garrido","sequence":"additional","affiliation":[{"name":"Catalan Institute of Nanoscience and Nanotechnology (ICN2) CSIC and BIST Campus UAB  Bellaterra 08193 Spain"},{"name":"ICREA  Barcelona 08010 Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9849-902X","authenticated-orcid":false,"given":"Xavier","family":"Navarro","sequence":"additional","affiliation":[{"name":"Institute of Neurosciences Department of Cell Biology Physiology and Immunology Universitat Aut\u00f2noma de Barcelona  Bellaterra 08193 Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red en Enfermedades Neurodegenerativas (CIBERNED) Instituto de Salud Carlos III  Madrid 28031 Spain"},{"name":"Institut Guttmann of Neurorehabilitation  Badalona 08916 Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,6,11]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"publisher","DOI":"10.1186\/1743-0003-8-53"},{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1085-9489.2005.10303.x"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2021.615218"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/ma13102344"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.a.20065"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1586\/erd.09.58"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1088\/1748-605X\/ad1f78"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/s21227581"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1088\/1741-2552\/ac1e45"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1088\/1741-2560\/10\/4\/046016"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1088\/1741-2552\/ad1611"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1109\/TBME.2006.886617"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bios.2010.05.010"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201700909"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1088\/2053-1583\/3\/2\/024004"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cobme.2018.06.001"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41565-023-01570-5"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2014.07.010"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2017.01.014"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.a.36274"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1088\/1741-2560\/11\/4\/046027"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-24502-z"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1109\/TNSRE.2019.2897256"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1109\/TBME.2011.2153850"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.21652"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1109\/TNSRE.2015.2440768"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.201200347"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201101503"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.5b05647"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.3171\/2013.1.PEDS12374"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2018.00001"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1166\/jbn.2013.1511"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.5b01290"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-20314-w"},{"key":"e_1_2_9_35_1","first-page":"1","volume":"15","author":"Nguyen D.","year":"2021","journal-title":"Front. Neurosci."},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/admi.201900229"},{"key":"e_1_2_9_37_1","doi-asserted-by":"crossref","unstructured":"J.Del Valle N.De la Oliva M.M\u00fcller T.Stieglitz X.Navarro presented atInt. IEEE\/EMBS Conf. Neural Eng. NER IEEE \u00a02015 pp.442\u2013445.","DOI":"10.1109\/NER.2015.7146654"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/ar.23920"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.bioeng.10.061807.160518"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropsychologia.2015.06.010"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1088\/1741-2560\/8\/3\/036023"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1088\/1741-2560\/12\/1\/016016"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1109\/TBME.2015.2406113"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1109\/TBME.2015.2466442"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1109\/10.237694"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1088\/1741-2552\/aa7586"},{"key":"e_1_2_9_47_1","first-page":"4123","volume":"2022","author":"Avdeew Y.","year":"2022","journal-title":"Ann. Int. Conf. IEEE Eng. Med. Biol. Soc."},{"key":"e_1_2_9_48_1","doi-asserted-by":"crossref","unstructured":"L.Gouyet G.Cath\u00e9bras S.Bernard D.Guiraud Y.Bertrand presented atProc. 3rd Int. IEEE EMBS Conf. Neural Eng IEEE \u00a02007 pp.578\u2013581.","DOI":"10.1109\/CNE.2007.369739"},{"key":"e_1_2_9_49_1","first-page":"148","volume":"25","author":"Soulier F.","year":"2008","journal-title":"Commun. Comput. Inf. Sci."},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.3390\/s21217219"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1186\/1743-0003-10-22"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41563-020-0679-7"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1109\/TBME.2003.820321"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2017.00497"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201901482"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41551-021-00732-x"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2022.09.003"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2014.02.008"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4886(82)90234-5"}],"container-title":["Advanced Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/advs.202308689","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T18:38:31Z","timestamp":1759775911000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/advs.202308689"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,11]]},"references-count":59,"journal-issue":{"issue":"29","published-print":{"date-parts":[[2024,8]]}},"alternative-id":["10.1002\/advs.202308689"],"URL":"https:\/\/doi.org\/10.1002\/advs.202308689","archive":["Portico"],"relation":{},"ISSN":["2198-3844","2198-3844"],"issn-type":[{"value":"2198-3844","type":"print"},{"value":"2198-3844","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,6,11]]},"assertion":[{"value":"2023-11-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-06-11","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"2308689"}}