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Herein, an innovative strategy is introduced that involves the use of a 3D\u2010printed, hollow microneedle array patch (MAP), in tandem with a vacuum tube (VT) connected through a hose, to improve ISF extraction efficiency and facilitate expedited analysis. The employment of negative pressure by the VT allows the MAP device to effectively gather \u224818\u00a0\u00b5L of ISF from the dermis of a live rabbit ear within a concise period of 5\u00a0min. This methodology enables the immediate and minimally invasive measurement of glucose levels within the body, employing personal healthcare meters for quantification. The fusion of the VT and MAP technologies provides for their effortless integration into a comprehensive and mobile system for ISF analysis, accomplished by preloading the hose with custom sensing papers designed to detect specific analytes. Moreover, the design and functionality of this integrated VT\u2010MAP system are intuitively user\u2010friendly, eliminating the requirement for specialized medical expertise. This feature enhances its potential to make a significant impact on the field of decentralized personal healthcare.<\/jats:p>","DOI":"10.1002\/advs.202308716","type":"journal-article","created":{"date-parts":[[2024,3,19]],"date-time":"2024-03-19T15:45:55Z","timestamp":1710863155000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":50,"title":["Enhanced Interstitial Fluid Extraction and Rapid Analysis via Vacuum Tube\u2010Integrated Microneedle Array Device"],"prefix":"10.1002","volume":"11","author":[{"given":"Yuanting","family":"Xie","sequence":"first","affiliation":[{"name":"Guangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging National\u2010Regional Key Technology Engineering Laboratory for Medical Ultrasound School of Biomedical Engineering Shenzhen University Medical School  Shenzhen 518060 China"},{"name":"Shenzhen Key Laboratory of Nano\u2010Biosensing Technology Marshall Laboratory of Biomedical 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