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Conversely, point\u2010of\u2010care devices paired with fingersticks, although less invasive, suffer from high variability and low blood volume collection. Recently approved microsampling devices address some of these issues but remain cost\u2010prohibitive for resource\u2010limited settings. In this work, a cost\u2010effective microsampling device is described for the collection of liquid blood with minimal invasiveness and sufficient volume retrieval for laboratory analyses or immediate point\u2010of\u2010care testing. Inspired by the anatomy of sanguivorous leeches, the single\u2010use device features a storage compartment for blood collection and a microneedle patch hidden within a suction cup. Finite Element Method simulations, corroborated by mechanical analyses, guide the material selection for device fabrication and design optimization. In piglets, the device successfully collects \u2248195\u00a0\u00b5L of blood with minimal invasiveness. Additionally, a tailor\u2010made lid and adapter enable safe fluid transportation and integration with commercially available point\u2010of\u2010care systems for on\u2010site analyses, respectively. Taken together, the proposed platform holds significant promise for enhancing healthcare in the pediatric population by improving patient compliance and reducing the risk of needlestick injuries through concealed microneedles. Most importantly, given its cost\u2010effective fabrication, the open\u2010source microsampling device may have a meaningful impact in resource\u2010limited healthcare settings.<\/jats:p>","DOI":"10.1002\/advs.202308809","type":"journal-article","created":{"date-parts":[[2024,3,7]],"date-time":"2024-03-07T05:59:36Z","timestamp":1709791176000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["A Bioinspired and Cost\u2010Effective Device for Minimally Invasive Blood Sampling"],"prefix":"10.1002","volume":"11","author":[{"given":"Nicole","family":"Zoratto","sequence":"first","affiliation":[{"name":"Institute of Pharmaceutical Sciences Department of Chemistry and Applied Biosciences ETH  Zurich 8093 Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Klein\u2010Cerrejon","sequence":"additional","affiliation":[{"name":"Institute of Pharmaceutical Sciences Department of Chemistry and Applied Biosciences ETH  Zurich 8093 Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Gao","sequence":"additional","affiliation":[{"name":"Institute of Pharmaceutical Sciences Department of Chemistry and Applied Biosciences ETH  Zurich 8093 Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tino","family":"Inchiparambil","sequence":"additional","affiliation":[{"name":"Institute of Pharmaceutical Sciences Department of Chemistry and Applied Biosciences ETH  Zurich 8093 Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Sachs","sequence":"additional","affiliation":[{"name":"Institute for Mechanical Systems Department of Mechanical and Process Engineering ETH  Zurich 8093 Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering Southern University of Science and Technology  Shenzhen Guangdong 518055 P.R. 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